Nippon Kayaku Kabushiki Kaisha

Yuya Nakayama

Tomio Takeuchi

Akira Matsuda

Mamoru Kunishima

Hamao Umezawa

Katsutoshi Takahashi

Kenji Iwata

This invention relates to a novel platinum-diamine complexes represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, ##STR2## or jointly represent a group represented by ##STR3## in which R.sub.3 is a lower alkyl group or a group represented by --OM (wherein M is an atom which can become a monovalent cation); Y is --OH or a halogen atom; and n is 0 or 1, and n is 1 when R.sub.1 and R.sub.2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.

Novel platinum complexes

Anti-tumor low-toxicity coriolin derivatives represented by the following general formula: ##STR1## wherein one of X and Y is ##STR2## and the other is &gt;C OH, &gt;C.dbd.O or ##STR3##

Coriolin derivatives

Coriolin derivatives having antitumor activity and low toxicity represented by the following general formula: ##STR1## where R: --CO(CH.sub.2).sub.6 CH.sub.3 or --COCH(OH)(CH).sub.2).sub.5 CH.sub.3,

Growing community of inventors

Omiya, Japan

Yuya Nakayama