Tsinghua University

Capitalbio Corporation

Aviva Biosciences Corporation

Capital Biochip Company Ltd

Yuxiang Zhou

Jing Cheng

Junquan Xu

Litian Liu

Depu Chen

Jia Wang

Weiping Yang

Ken Chen

Huafang Gao

Xiaoshan Zhu

Zhiming Li

Zewen Liu

Zhimin Tan

Xuezhong He

Wenzhang Xie

Dong Wang

Can Wang

Xiaobo Wang

Rui Zhang

Jing Zhu

Zhiwei Zhang

Chi Zhang

Lei Wu

Wanli Xing

Qian Chen

Di Jiang

Guangxin Xiang

Wei Shao

Qiong Zhang

Lianghong Guo

Zhongyao Yu

Wenjun Yang

Huawei Yang

Yue Tian

Guangshun Yi

Yimin Sun

Baoquan Sun

Lingxiang Zhu

Liangbin Pan

Weiyang Fei

Yue Ge

Yiming Zhou

Gengxin Lan

Ning Du

Xiumel Liu

Xiumei Liu

Xuemei Ma

Yizhe Zhang

Huajiang Wei

Jiying Qiao

Yongchao Zhao

Lihua Huang

Xu Teachers College Of Prof Tehcnology Zhang

A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

Automatic positioning and sensing microelectrode arrays

A testing method of nucleic acid binding protein based on biochip, comprises the following steps: 1. puts a plurality of groups solution including nucleic acid captured probes into biological sample including a plurality of nucleic acid binding protein to be test, and thus forming nucleic acid captured probe-nucleic acid binding protein complexes; such nucleic acid captured probe includes at least a segment of binding sequence which can bind with aimed nucleic acid binding protein; 2. separates such nucleic acid captured probe-nucleic acid binding protein complexes, then recoveries nucleic acid captured probes; 3. hybridizes the nucleic acid captured probes according to step 2 with a plurality of single strand blotting probes on biochip substrate; the sequence of such blotting probe compensates with such nucleic acid captured probe or one of its strand; 4. detects the result of hybridization.

Testing method of nucleic acid binding protein based on biochip

The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.

Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria

This invention relates generally to the field of nucleic acid analysis. In particular, the invention provides a method for typing a target gene, using, inter alia, a chip comprising a support suitable for use in nucleic acid hybridization having immobilized thereon an oligonucleotide probe complementary to said target nucleotide sequence and at least one of the following oligonucleotide control probes: a positive control probe, a negative control probe, a hybridization control probe and an immobilization control probe. Oligonucleotide probes or probes arrays for typing a HLA target gene are also provided.

DNA chip based genetic typing

Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

Nanometer-sized up-converting phosphor fluoride particles and process of preparation

This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.

Individually addressable micro-electromagnetic unit array chips

The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.

Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Growing community of inventors

Beijing, China

Yuxiang Zhou