Illumina Corporation

Illumina Cambridge Limited

Yuxiang Huang

James M Tsay

David Louis Heiner

Alexandre Richez

John M Beierle

Sean M Ramirez

Sang Ryul Park

Kevan Samiee

Ludovic Vincent

Peyton Shieh

Wei Wei

Anmiv Prabhu

Tyler Jamison Dill

Scott William Bailey

Robert Yang

Edwin Li

Naiqian Zhan

Valerie Uzzell

Kristina Munoz

Leonid Malevanchik

Samantha Schmitt

Sunmin Ahn

James Tsay

A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.

Flow cell package and method for making the same

An example of an array includes a support including a plurality of discrete wells, a gel material positioned in each of the discrete wells, a sequencing primer grafted to the gel material, and a non-sequencing entity grafted to the gel material. Each of the sequencing primer and the non-sequencing entity is in its as-grafted form.

Array including sequencing primer and non-sequencing entity

Growing community of inventors

San Diego, CA, United States of America

Yuxiang Huang