Leland Stanford Junior University

Yuval Rinkevich

Irving L Weissman

Jonathan Tsai

Rahul Sinha

Nathaniel Fernhoff

Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.

Methods and compositions for the prevention and treatment of surgical adhesions

Populations enriched for smooth muscle progenitors are obtained by selection on the basis of expression of specific cell surface markers.

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Munich, Germany

Yuval Rinkevich