Shionogi Company Limited

Yuusuke Tamura

Yukio Tada

Shuji Yonezawa

Shinji Suzuki

Eiichi Kojima

Yuuji Kooriyama

Tatsuhiko Ueno

Chiaki Fujikoshi

Sae Matsumoto

Toshihiro Wada

Yuki Murakami

Yu Hinata

Hiroki Ozasa

Naoki Omori

Kenichi Ishibashi

Kyohei Hayashi

Hidaka Ikemoto

Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.

Salts of quinazoline derivative or crystals thereof, and the process for producing thereof

Provided is a compound which is useful as an AMPK activator. The compound is represented by formula: wherein the symbols are defined in the specification.

5-phenylazaindole derivative having AMPK-activating activity

Provided is a compound which is useful as an AMPK activator, represented by formula: 

5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt,whereinX is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl;Ris hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl;Ris halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like;Ris halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; andRis hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.

Azaindole derivative having AMPK-activating activity

A compound is represented by formula: or its pharmaceutically acceptable salt, wherein Y is substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl; T is &#x2014;CR&#x2550; or &#x2014;N&#x2550;; U is &#x2014;CR8&#x2550; or &#x2014;N&#x2550;; Ris hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, alkenyl, acyl, carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, or alkyloxycarbonyl; Ris halogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocyclyl; and R, Rand Rare each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl.

Indole and azaindole derivative having AMPK-activating activity

This invention provides new compounds having NPY Y5 antagonistic activity. The present inventors found that a compound of the formula (I): wherein Ris substituted or unsubstituted alkyl or the like; p, q and r are each independently 0 or 1; ring A is oxadiazole; and Ris substituted or unsubstituted alkyl or the like, has NPY Y5 antagonistic activity.

5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity

This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; Rand Rare each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R, R, Rand Rare each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.;a pharmaceutically acceptable salt or solvate thereof,which is useful for treating diseases induced by production, secretion and/or deposition of amyloid &#x3b2; protein.

Growing community of inventors

Osaka, Japan

Yuusuke Tamura