Ajinomoto Co., Ltd.

Yuuichi Aoki

Kazutaka Nagashima

Eriko Ono

Tadashi Takemoto

Yusuke Amino

Shigeru Kawahara

Yutaka Sato

Nao Funakoshi

Shinji Fujita

N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-&#x3b1;-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same. Further, there are provided a process for producing dialkoxychroman derivatives useful as intermediates for the production of such aspartame derivatives in the above process, and novel dialkoxychroman derivatives thus produced, which are excellent as the production intermediate.

Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates

N-&lsqb;N-&lsqb;3-(3-hydroxy-4-methoxyphenyl)propyl&rsqb;-L-&agr;-aspartyl&rsqb;-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercial product.

Crystals of aspartame derivative

The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.

Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof

Herein are disclosed a process for producing xylitol of high purity (one-step desalting process) which comprises the steps of (1) removing the solid matter from a culture froth obtained by culturing a xylitol-producing microorganism in an aqueous culture medium, (2) desalting the resulting solid matter-removed culture broth by removing the ionic substances therefrom by means of a cation-exchange resin and an anion-exchange resin, (3) subjecting the resulting desalted solution to the chromatography using a strongly acidic cation-exchange resin to separate the xylitol from the other sugar alcohol(s) and sugar(s), and (4) obtaining the xylitol by separating it at a high purity from the resulting xylitol solution (fraction), and to a similar process (two-step desalting process) but wherein the desalting carried out twice by adding the ion-exclusion step between Steps (1) and (2) of the above-mentioned process, whereby most of the ionic substances are removed, by which processes highly pure xylitol can be obtained from a xylitol solution in a commercially effective way, in the method for producing xylitol by using a xylitol-producing microorganism.

Process for producing xylitol of high purity

The present invention provides an acetone adduct of V-28-3M to be used as an intermediate for producing V-28-3M which is useful as a fungicide, a process for producing it and a process for purifying V-28-3M. When crude V-28-3M is dissolved in acetone, an acetone adduct of V-28-3M is to remarkably improve the crystallization rate and, accordingly, also to remarkably improve the purity. The obtained acetone adduct can be easily hydrolyzed to obtain pure V-28-3M.

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Kawasaki, Japan

Yuuichi Aoki