Okinawa Research Center Co., Ltd.

University of the Ryukyus

University of the Ryunkyus

Yuto Teruya

Je-Tae Woo

Toshiaki Teruya

Kozue Sasaki

Saki Sugiyama

Aki Yamano

Kosuke Sueyoshi

Miki Yamada

The object is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization. The method includes (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product; (1-2) a step of drying the hot water-treated product to obtain a dried product; (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution; (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate; and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.

Method for manufacturing composition containing nobiletin and tangeretin derived from citrus fruits, and composition containing nobiletin and tangeretin obtained thereby

An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques. The objective is solved by A method for producing a nepodin-containingplant extract, the method comprising the following steps (1) to (5): (1) a step of subjecting aplant to an extraction treatment using a nepodin-dissolving solvent to obtain a crudeplant extract; (2) a step of subjecting the crudeplant extract to a water-adding treatment and/or concentration treatment to obtain a solid crudeplant extract; (3) a step of subjecting the solid crudeplant extract to a weak alkali treatment to obtain a weak alkali insoluble product; (4) a step of subjecting the weak alkali insoluble product to a strong alkali treatment to obtain a strong alkali soluble product; and (5) a step of subjecting the strong alkali soluble product to a neutralization treatment to obtain the nepodin-containingplant extract.

Method of producing high-nepodin-containing rumex plant extract and high-nepodin-containing rumex plant extract

Growing community of inventors

Nakagami-gun, Japan

Yuto Teruya