Nagasaki University

Yutaro Tsuda

Osamu Onomura

Toshiharu Yanagi

Kazuya Kodama

Masami Kuriyama

Provided is a process for producing an optically active compound represented by Formula (3): (wherein Ris an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of Rmay be replaced with a substituent; Ris a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein Rand Rhave the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2):MZ&#x2003;&#x2003;(2)(wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.

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Nagasaki, Japan

Yutaro Tsuda