Kyoto Daiichi Kagaku Co., Ltd.

Kurashiki Boseki Kabushiki Kaisha

Yutaka Yamasaki

Harumi Uenoyama

Kexin Xu

Hideo Ueda

Takeshi Sakura

Mitsuo Hiromoto

Meng Gang

Motonobu Shiomi

Xiaoming Dou

Yoshinori Yamaguchi

Hiroko Kubo

Hisashi Okuda

Emi Ashibe

Naoki Yanai

Eiichi Kimura

Koji Matsuoka

A light source pa light of a plurality of wavelengths of a near infrared region, and a spectroscopic part selects a wavelength subjected to absorption by lactic acid as a measuring wavelength from measuring light of a plurality of wavelengths emitted from the light source part. A probe comes into contact with an organism measuring portion and irradiates the organism measuring portion with the measuring light of the wavelength selected by the spectroscopic part, while a photoreceiving part detects transmitted/scattered light of the measuring light incident upon the organism measuring portion. A light signal detected by the photoreceiving part is converted to absorbance in a signal processing part, so that the concentration of lactic acid is calculated by a host computer serving as an arithmetic-control part and displayed on a display part. No reagent is required, while difference between lactic acid concentrations varied with measuring portions can also be noninvasively measured.

Method of and apparatus for measuring lactic acid in organism

In an optical measuring apparatus of the present invention, a spectroscopic optical system emits a measuring light beam that contains a measure light component of a measure wavelength domain where a measured object absorbs part of the light and a reference light component of a reference wavelength domain where the measured object almost completely absorbs the light, and separates the beam into beams, a photometric unit measures the light incident on an integrating sphere when a reference sample is inserted in the light path and stores the measurements in a memory and also measures the light incident on an integrating sphere when a measured object is inserted in the light path, and an arithmetic circuit calculates a light intensity ratio of the compensation light component for the measured object to the compensation light component stored in memory and then estimates background intensities during the measurement by multiplying the measurements stored in the memory by the intensity ratio.

Spectrometry and optical method and apparatus for obtaining a stable

As to reaction solutions in which the amount of each potassium ferricyanate, glucose oxidase and glucose substrate are set at a constant value while glucose concentrations are varied, intensity changes of peaks at a shift wavenumber of 2081 cm.sup.-1 in light scattering spectra are measured every 10 seconds, the maximum values of the intensity changes of the peaks at the respective glucose concentrations obtained, for obtaining a calibration curve from correlations between the maximum values of the reaction velocities and the glucose concentrations. The calibration curve is employed for carrying out quantitative measurement of an unknown sample.

Method of measuring enzyme reaction by Raman scattering

A method of quantitative analysis of a specific component of an object to be measured comprises steps of measuring an energy spectrum of light transmitted through or reflected from the object, dividing the energy spectrum into a plurality of wavelength domains, thereby obtaining a plurality of partial energy spectra, normalizing the plurality of partial energy spectra within each wavelength domain using an energy measured at a predetermined wavelength contained in each wavelength domain, and performing the quantative analysis by multivariate analysis using the plurality of partial energy spectra having been normalized.

Method of stabilizing spectra in spectrometry

An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.

Apparatus and method for optically measuring concentrations of components

A syringe for collecting expiration is switched, to be connected by a three-way electromagnetic valve, between an expiration blowing part and a measuring part, so that expiration, blown from the expiration blowing part, is collected in the syringe while replacing old expiration. A switching valve is closed upon completion of exhalation so that end-tidal air is collected in the syringe. Thereafter the expiration sample is introduced into the measuring part from the syringe so that a constant amount of the expiration sample is collected by the measuring part to be introduced into a column.

Expiration collecting method and automatic expiration collector

An expiration suction passage communicating with an expiration blowing part provided with a non-airtight mask is connected to a forward end surface of a syringe through a two-way on-off electromagnetic valve, while an expiration transmission passage communicating with a sample outlet is also connected to the forward end surface of the syringe. A two-way on-off electromagnetic valve is provided in the expiration transmission passage, and an O.sub.2 sensor is provided between the electromagnetic valve and the sample outlet as a standard gas sensor. The syringe has a capacity capable of collecting several breaths, and a sucking operation is driven at a speed for collecting several breaths in single suction.

Expiration collector

A first sample measuring passage provided between a collection port and a suction pump has a sample gas measurer for measuring expiration components, while a second sample measuring passage which is provided in parallel with the first sample measuring passage has a standard gas measurer for measuring O.sub.2 gas. Assuming that [A] represents a measured value of a target component in an expiration sample and [b.sub.1 ] represents O.sub.2 concentration in the expiration sample, correction is made on the basis of:

Method of correcting componential concentration in expiration and

An apparatus and method for measuring component concentrations which enables accurate measurement of concentrations of component within an object in a non-destructive, non-invasive, and bloodless procedure. The apparatus comprises a light irradiator 1 for projecting pulse laser of different wavelengths toward an object 12 by means of a variable wavelength laser generating unit 11, a photodetector 2 for performing a time resolved measurement of the quantity of transmitted light from the object which is subject to changes with lapse of time after the generation of the pulse laser, and an arithmetic unit 3 for calculating concentrations of components in the object 12 and outputting the calculation result such that the relationship between time lapse and measured quantity of light is converted into a relationship between an optical path length representing the distance of light travel within the object 12 and a change in the measured quantity of light relative to a change in unit concentration so that the optical path length and the quantity of light which is measured when the change in the quantity of light is at a peak are stored in memory for each wavelength, the quantity of light being used as a basis for the calculation.

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Kyoto, Japan

Yutaka Yamasaki