Shionogi & Company Limited

Yutaka Tomida

Yoshinori Tamura

Toshiyuki Akiyama

Akira Matsumura

Shuichi Sugiyama

Manabu Katou

Toshihiro Wada

Naotake Kobayashi

Yoshikazu Sasaki

Naoki Ohyabu

Yuji Nishiura

Masafumi Iwatsu

Takatsugu Inoue

Keisuke Miyazaki

Kana Kurahashi

Masataka Fumoto

Tomomi Urabe

Kentarou Asahi

Masahide Ohdan

The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same. The compound represented by the formula: wherein Ais CR, CRR, N or NR; R, R, Rand Rare each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted non-aromatic carbocyclyl; Ris a hydrogen atom, substituted or unsubstituted alkyl, or substituted or unsubstituted non-aromatic carbocyclyl; ring Tis substituted or unsubstituted nitrogen-containing non-aromatic heterocycle; Ris a hydrogen atom, halogen, cyano, or substituted or unsubstituted alkyl; Ris each independently substituted or unsubstituted alkyl or the like: n is 1 or 2; Ris substituted or unsubstituted aromatic carbocyclyl or the like; Ris a hydrogen atom or a carboxy protecting group.

Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity

The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I): 

Alkylene derivatives

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Toyonaka, Japan

Yutaka Tomida