Kyowa Hakko Kogyo Co., Ltd.

Yutaka Takano

Akio Ozaki

Ryoichi Katsumata

Katsuhiko Ando

Keiko Ochiai

Hideo Mori

Hiroaki Motoyama

Masaru Hasegawa

Masato Ikeda

Tetsuo Nakano

Nozomu Kamada

Attempts are made to provide a novel transaldolase gene; a polypeptide encoded by this gene; a recombinant DNA obtained by integrating this gene; a microorganism carrying this recombinant DNA; and a process for producing an aromatic amino acid, an aromatic vitamin, L-histidine, riboflavin, a nucleic acid, a nucleic acid-associated substance, a novel saccharide, etc. by using the above microorganism. As the results of extensive studies, a novel transaldolase gene is isolated from chromosomal DNA of a microorganism belonging to the genusas a DNA fragment complementary to the requirement for shikimic acid of a transketolase defective variant obtained as a variant with the requirement for shikimic acid belonging to the genus. Further, a recombinant DNA containing this gene is constructed and transferred into a host microorganism, thereby achieving the objects as described above.

Transaldolase gene

Bacillus strains which produce HMG-CoA reductase inhibitors

Disclosed is a process for producing a compound represented by general formula (II-a):

Process for the preparation of HMG-COA reductase inhibitors

The present invention provides a gene expression regulatory DNA and a process for preparing a protein using the same. A DNA derived from the isocitrate lyase (ICL) gene of a coryneform bacterium regulates expression of a structural gene encoding a protein when incorporated into a vector DNA together with said structural gene and introduced into a host coryneform bacterium, and a useful protein can be efficiently produced using the DNA.

Gene expression regulatory DNA

Growing community of inventors

Machida, Japan

Yutaka Takano