Towa Pharmaceutical Co., Ltd.

Yutaka Okuda

Masaki Sato

Tomoaki Okushima

Tatsuya Honjo

Isamu Saeki

Kayo Yuminoki

Megumi Murahashi

Keigo Nakamura

Hiroko Kabashima

Yuki Matsushima

Masking particles which comprise a drug-containing particle containing a drug, an acid, and a carbonate, the drug-containing particle being coated with a coating layer containing a water-insoluble polymer sufficiently suppress drug release in the oral cavity and pharynx, rapidly release a drug after swallowing, and easily control the release suppression time of a drug. The acid may be at least one organic acid. The carbonate may be at least one water-soluble carbonate. Oral pharmaceutical compositions include tablets, granules, fine granules, powders.

Timed-elution masking particles and oral pharmaceutical composition containing the same

An orally disintegrating tablet is disclosed possessing both advantageous hardness and disintegrability. The orally disintegrating tablet is (a) a compression molding product of a mixture comprising: a pharmaceutically active ingredient-containing composition selected from a group consisting of a pharmaceutically active ingredient-containing powder and pharmaceutically active ingredient-containing granules; rapidly disintegrating granules; and a lubricant, (b) wherein the rapidly disintegrating granules comprise a sugar and/or a sugar alcohol, and one or more organic and/or inorganic, hydrophilic and water-insoluble additives.

Orally disintegrating tablet

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Kadoma, Japan

Yutaka Okuda