Ihara Chemical Industry Co., Ltd.

Yutaka Ohishi

Chihiro Yazawa

Yoshiki Nakayama

Yasushi Higuchi

Taro Izawa

Masahiro Matsuno

A catalyst of bis(8-quinolinolate) copper (II) complex having the formula ##STR1## which is used for producing a hydroxyphenyl aliphatic acid derivative having the formula ##STR2## wherein R.sub.1 represents hydrogen atom, a lower alkyl group, a lower alkoxy group, hydroxy group or a lower alkylcarbonyl group; R.sub.2 and R.sub.3 are the same or different and respectively represent hydrogen atom or a lower alkyl group; and m is 1 or 2; l is 0, 1 or 2; n is 0, 1 or 2; by reacting a halophenyl aliphatic acid derivative having the formula ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, m, l and n are defined above and R.sub.4 represents hydrogen atom or a monovalent hydrocarbon moiety; and X represents a halogen atom, with a base.

Process for producing hydroxyphenyl aliphatic acid derivatives

A process for producing tolylthiourea having high purity comprises reacting toluidine with a thiocyanate and a mineral acid in the presence of an organic solvent and water.

Process for producing tolylthiourea having high purity

An inert organic solvent dispersion of alkali hydroxide is prepared by mixing an alkali hydroxide, an inert organic solvent and a stabilizer and heating and stirring at the temperature for forming the pasty alkali hydroxide and cooling the dispersion. The dispersion of alkali hydroxide is used in a reaction of an active methylene compound with an organoalkyl halide such as a reaction of a halophenylacetonitrile with an isopropyl halide to obtain .alpha.-isopropyl halophenylacetonitrile.

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Shizuoka, Japan

Yutaka Ohishi