Otsuka Pharmaceutical Company, Limited

Osaka Pharmaceutical Co., Ltd.

Yutaka Ohbuchi

Masato Horie

Yoshihiro Taniguchi

Mikio Suzuki

Keiichi Okutomi

Hideo Tanaka

Takashi Suzuki

Kenji Yoshida

Seiji Akamatsu

Takumi Sumida

Yasuo Yanagihara

Masaaki Motoyama

Kazuhisa Sugiyama

Kazuo Sekiguchi

Takeshi Kodama

Mitsuhiro Okuno

Kunihiko Kiyono

Naoto Ohi

Takashi Watanabe

Kenji Ohnishi

Kazuhiko Hayashi

An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;, Rrepresents a group &#x2014;Z&#x2014;R, in which Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014; or the like, Rrepresents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, Rrepresents a hydrogen atom or a halogen atom, Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014; or a lower alkylene group, and A represents a group wherein Rrepresents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, Rrepresents an imidazolyl lower alkyl group or the like.

STAT3/5 activation inhibitor

The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.

Ly6h polypeptide

The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.

Ly6H gene

Growing community of inventors

Tokushima, Japan

Yutaka Ohbuchi