Toray Industries, Inc.

Yutaka Nishimura

Hiroyuki Meguro

Mie Kaino

Yukihiro Nishio

Tomohide Masuda

Keiichi Okimura

Yuko Kubota

Hideyuki Tsutsui

Syuji Udagawa

Masashi Yamamoto

Yumiko Sekiya

A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein, Ris trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each Ris independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; Ris a hydrogen atom, halogen atom, C-Calkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or RO&#x2014;; and Ris phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R.

Urea derivative and use therefor

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Kamakura, Japan

Yutaka Nishimura