Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Yutaka Mukaida

Hitoshi Takita

Satoru Enomoto

Sakuo Noda

Mikiro Yanaka

Hisayuki Wada

Hidetoshi Kobayashi

Sadao Nishita

Fumihiko Kimura

Toyohiko Nitta

Kazuyoshi Inada

Kohju Watanabe

Kiyonori Umekawa

Mari Toji

Toshihiko Wada

Azuma Okubo

Akiyoshi Nakajima

Kobayashi, Hidetoshi

Disclosed herein are a derivative of dihydroxybenzamide represented by the formula(I): ##STR1## wherein (1) R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a straight chain-alkyl group of 4 to 12 carbon atoms, a branched chain-alkyl group of 4 to 12 carbon atoms, a cyclo-alkyl group of 4 to 12 carbon atoms, ##STR2## wherein n is an integer of 1 to 6, or a pyridyl group which is substituted or unsubstituted, or (2) R.sup.1 and R.sup.2 are cyclized to make a heterocycle containing amino group represented by the formula ##STR3## wherein X represents a nitrogen atom or a methine and Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a phenyl group, and a pharmaceutical composition containing the same.

Derivative of dihydroxybenzamide and a pharmaceutical composition thereof

The present invention discloses a method for treating a patient suffering from osteoarthritis comprising administering a physiologically effective amount of pharmaceutical composition containing at least one compound, as an active ingredient, represented by the formula (I): ##STR1## wherein R represents a hydrogen atom or an acyl group; X represents a CHO group, a COOH group, a physiologically acceptable salt thereof or a CH(OR').sub.2 group wherein R' represents an acyl group.

Treating agent for osteroarthritis

Disclosed herein are dialkanoyloxybenzylidene dialkanoate represented by the formula ##STR1## wherein X.sup.1 and X.sup.2 represent respectively alkanoyloxy group and a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of inflammatory disease of the dialkanoyloxybenzylidene dialkanoate as an active ingredient thereof.

Dialkanoyloxybenzylidene dialkanoate

Disclosed herein are dialkanoyloxybenzylidene dialkanoate represented by the formula, ##STR1## wherein X.sup.1 and X.sup.2 represent respectively alkanoyloxy group and a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of inflammatory disease of the dialkanoyloxybenzylidene dialkanoate as an active ingredient thereof.

Derivative of dihydroxybenzamide and a pharmaceutical composition having

Disclosed herein are a pharmaceutical composition for treating nephritis, comprising at least one compound selected from the group consisting of the derivatives of N-(dihdyroxybenzylidene)amino acid, represented by the formula (I): ##STR1## wherein R represents an alkylene group having one to five carbon atoms, a phenylene group or ##STR2## the pharmaceutically acceptable salts and esters thereof, and a pharmaceutically acceptable carrier therefor, and the method for treating nephritis.

Pharmaceutical composition for treating nephritis and method for

A novel compound of 4-[N-(hydroxybenzyl)aminomethyl]-cyclohexane-1-carboxylic acid represented by the general formula (I): ##STR1## wherein n is an integer of 1 to 3, or a salt or an ester thereof which has specific pharmacological activities, a method for preparing the derivative and a pharmacological composition in dosage unit form comprising the derivative as an active ingredient are disclosed herein.

4-[N-(Hydroxybenzyl)aminomethyl]cyclohexane-1-carboxylic acid

A novel derivative of dihydroxybenzoic acid represented by the formula (I) ##STR1## wherein R represents ##STR2## or a salt or an ester thereof which has specific pharmacological activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Derivatives of dihydroxybenzoic acid and pharmaceutical composition

A novel compound of 4-[N-(3',4'-methylenedioxybenzylidene) aminomethyl]cyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt or an C.sub.1 -C.sub.4 alkyl ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

4-(N-(3',4'-Methylenedioxybenzylidene)-aminomethyl)cyclohex

A novel compound of 4-[N-(3',4'-dihydroxybenzylidene) aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Derivative of 4-(N-(3,4-dihydroxybenzylidene) aminomethyl

A novel compound of 4-[N-(substituted-benzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Derivative of 4-(N-(substituted-benzylidene)amino-methyl

Disclosed is a method for producing the high-quality mycelia of the Basidiomycetes from culture thereof by promoting growth of the fungus as well as differentiation of the cells and attendant organization thereof by adding to the culture medium a straight chain saturated aliphatic alcohol with a catbon number within a specified range of 26 to 36 carbon atoms.

Growth promoting method for basidiomycetes

Disclosed herein is a process for preparing a normal long chain alkanoic acid having 26 to 36 carbon atoms, in which a trihalogenomethane is added to a normal alpha-olefin having 25 to 35 carbon atoms in the presence of a radical initiator and then the thus formed 1,1,1-trihalogenoalkane is hydrolyzed with an alkali to convert into the normal long chain alkanoic acid.

Process for preparing a normal long chain alkanoic acid

The palladium complex disclosed herein is bis[tri(ortho-tolyl)phosphine] :palladium which is produced by reacting a palladium salt with tri(ortho-tolyl)phosphine and reducing the resultant bis[tri(ortho-tolyl)phosphine] palladium salt with an alcoholic alkali. This complex is useful as a catalyst for the production of 1,3-diene oligomers.

Palladium complex, process for the preparation thereof and catalyst for

The palladium complex disclosed herein is bis[tri(orthotolyl)phosphine] palladium which is produced by reacting a palladium salt with tri(ortho-tolyl)phosphine and reducing the resultant bis[tri(ortho-tolyl)phosphine] palladium salt with an alcoholic alkali. This complex is useful as a catalyst for the production of 1,3-diene oligomers.

Growing community of inventors

Tokyo, Japan

Yutaka Mukaida