3m Innovative Properties Company

Daiichi Sankyo Company, Limited

Ebara Corporation

Peptidream Inc.

Yutaka Mori

Takahiro Yamaguchi

Takeshi Honda

Takahiro Oshita

Hidetoshi Abe

Keiji Saito

Yorinobu Takamatsu

Hideki Kubota

Akihiro Furukawa

Mitsuhiro Iwamoto

Takahiro Nagayama

Patrick Reid

Takahide Okuyama

Hironao Saito

Hajime Chisaka

Eri Otsuka

Hiroshi Ijiri

Yutaka Ishigai

Aizo Sakurai

Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia. Specifically provided is a macrocyclic polypeptide represented by formula (I) [wherein A is selected from the linking groups Ato A; Xis a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent; Xis a residue of an aromatic amino acid or a neutral amino acid; Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid; Xis Ser, Thr, Ala, orS; Xis Gly or Ser; Xis a residue of a basic amino acid or a neutral amino acid; Xis a residue of a neutral amino acid or an acidic amino acid; Xis a residue of an aromatic amino acid; Xis a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid; Xis a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid; Xis a residue of an aromatic amino acid; and Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof.

Thrombospondin 1-binding peptide

The present invention provides a modified atrial natriuretic peptide that exhibits prolonged duration in blood and maintains cGMP elevating activity. The present invention provides a modified peptide in which at least one sugar substance is linked directly through a glycosidic bond or via a linker structure to at least one hANP peptide, or a pharmaceutically acceptable salt thereof, a medicament comprising the modified peptide or the salt thereof as an active ingredient, etc.

Glyco-modified atrial natriuretic peptide

To provide a film having high tensile strength and elongation characteristics. A methacrylic film formed of (A) a carboxyl group-containing (meth)acrylic polymer having a glass transition temperature (Tg) of 0&#xb0; C. or higher and a weight-average molecular weight of 10,000 or more obtained by copolymerizing a composition containing a monoethylenically unsaturated monomer as a main component and an unsaturated monomer having a carboxyl group, and (B) an amino group-containing (meth)acrylic polymer having a glass transition temperature (Tg) of 0&#xb0; C. or lower and a weight-average molecular weight of 10,000 or more obtained by copolymerizing a composition containing a monoethylenically unsaturated monomer as a main component and an unsaturated monomer having an amino group, wherein a mixing ratio of the component (A) to the component (B) is from 10:90 to 90:10 in terms of a weight ratio.

(Meth)acrylic film, and making film and receptor sheet using the same

A decorative film using no appreciable amount, or no amount, of polyvinyl chloride. In a decorative film comprising a substrate and an adhesive layer formed on one surface of the substrate, the substrate is formed from an ethylene-(meth)acrylic acid copolymer.

Decorative adhesive films

A marking film exhibiting good ability for tracing curved surfaces when it is to be stuck to steeply curved three-dimensional portions without entrapping air bubbles at the film edges when an over-clear coating is applied thereon after it has been stuck. The marking film has a marking component to be transferred onto an article via an adhesive layer, wherein the total thickness of the marking film is in the A range of from about 50 &mgr;m to about 300 &mgr;m, and the modulus of elasticity thereof is in the range of from about 2 kgf/mm to about 25 kgf/mm as measured under a condition where the marking film is elongated at a tension speed of 300 mm/min. into an elongation percentage in the range of 0 to about 10%.

Marking film and composite marking film

To provide a decorative sheet which has a three-dimensional decorative effect and, in addition, is free from separation of a decorated area upon being exposed to abrasion or impact conditions. A decorative sheet comprising: a substrate ( ) formed of a transparent resin composition; and, laminated thereon in the following order, a color layer ( ), an expandable layer ( ), and a pressure-sensitive adhesive layer ( ).

Decorative sheet and process for producing the same

Retroreflective sheet

A method and apparatus for recovering energy from wastes is used for recovering energy by gasifying wastes such as municipal waste. The method comprises gasifying wastes in a fluidized-bed gasification furnace at a relatively low temperature; introducing gaseous material and char produced in the fluidized-bed gasification furnace into a melting furnace; gasifying the gaseous material and char in the melting furnace at a relatively high temperature; introducing gas produced in the melting furnace into a heat exchanging unit; and delivering heat recovered in the heat exchanging unit to a heat cycle to generate electric energy.

Method and apparatus for recovering energy from wastes

A retroreflective sheet capable of exhibiting an excellent decorative effect during both daytime and nighttime, and particularly an excellent rainbow-colored decorative effect. The sheet comprises, in order, a binder in the back side of which a plurality of microspheres, arranged in a monolayer, are partially embedded, a focusing layer underlying some of the microspheres, and a reflective layer underlying the focusing layer and underlying microspheres which do not have a focusing layer therebehind. The focusing layer has a film thickness selection coefficient x in the range of 0.16 to 0.95 as defined by equation (II) of the following equations (I) and (II): ##EQU1## wherein f is the coefficient for the optimum layer thickness of the layer, d is the diameter of the microspheres, h is the thickness of the focusing layer, n.sub.b is the refractive index of the binder layer, n.sub.g is the refractive index of the microspheres, and n.sub.s is the refractive index of the focusing layer.

Retroreflective sheet comprising microspheres, the diameter and

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Tokyo, Japan

Yutaka Mori