Other

Yutaka Miyauchi

Shigeo Hasegawa

Kanki Komiyama

Kazuhiko Otoguro

Citrus amanatsudaidai peel extract, which was used as a starting materials was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. Hair growers containing the peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

Peptides and hair growers having actions of promoting proliferation of

Astragali radix extract, which was used as a starting material, was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. The peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

Hair growers having actions of promoting proliferation of hair papilla

A hair grower consisting of each extract from the skin of a navel orange, the skin of an iyokan (Citrus iyo), the skin of a hassaku (Citrus hassaku), the skin of a sweet summer orange, the skin of a lemon, the skin of a mandarin orange, an aloe, all of said extracts are prepared by extracting with sake. The hair grower has an exellent hair-growing effect to positively promote the growth of human hair.

Growing community of inventors

Takasaki-Shi-Gunma-Ken, Japan

Yutaka Miyauchi