The Furukawa Electric Co., Ltd.

Mazda Motor Corporation

Other

Chugai Seiyaku Kabushiki Kaisha

Osaka University

Sapporo Breweries Limited

Furukawa Electric., Ltd.

Yutaka Matsuda

Yoshikazu Nobutoki

Hiroaki Sakamoto

Hiroo Moriue

Osamu Michihira

Kiyoshi Inoue

Seiji Hirano

Kyosuke Hashimoto

Yusaku Himono

Eiji Ichii

Teruhisa Inoue

Tomoyuki Igawa

Yuji Hori

Satoshi Kawai

Shun Shimizu

Koji Terayama

Hiroki Kawauchi

Kanako Tatsumi

Masaki Kamimura

Hiroki Hayashi

Yuichi Ito

Toshitaka Hara

Yasunori Komori

Hitoshi Katada

Hiroaki Susumu

Minoru Asano

Hideki Kimura

Yuichi Watanabe

Kazushi Shikata

Shoji Hara

Hiroshi Matsunaga

Satoshi Mizutani

Ikuo Hayashi

Toshimichi Tokunaga

Fumio Asakura

Kunio Odaka

Shigeto Tsuge

Takezo Sugimura

Taro Miyazaki

Shimon Sakaguchi

Toshiaki Tsunenari

Shigeki Motomura

Hiroji Oishibashi

Kenji Taniguchi

Hideki Nakazono

Yoichi Kozaki

Yoshio Shinoda

Mitsutaka Ohara

Ryuzo Shimizu

Yukio Fukushima

Yoshifumi Yasunaga

Kyosuke Hasimoto

Makoto Muto

Kyousuke Hashimoto

Makoto Mutoh

Tetsu Hamaguchi

Mitsuru Akimoto

Koji Umegaki

The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Pc region and methods of producing and using the polypeptides.

Anti-CTLA-4 antibody and use thereof

The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.

The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.

Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function

Provided are a beverage having an effectively improved flavor, and methods for the same. A method of producing a beverage according to the present invention is a method of producing a beverage using a raw material solution, the method including: washing barley without germinating the barley; discarding a wash solution after the washing of the barley; and preparing the raw material solution using a raw material containing the washed and ungerminated barley.

Barley beverage and method relating to same

Disclosed is a wire harness mounting method for mounting a wire harness to a wire harness holding portion provided on a vehicle-mounted component, such as an air conditioning duct, wherein the wire harness consists of two or more sub wire harnesses produced separately, the sub wire harnesses being arranged on the wire harness holding portion and collectively held by the wire harness holding portion to thereby complete the mounting of the wire harness.

WIRE HARNESS MOUNTING METHOD, WIRE HARNESS MOUNTING PORTION STRUCTURE, WIRE HARNESS MOUNTING TYPE VEHICLE COMPONENT, WIRE HARNESS MOUNTING TYPE VEHICLE COMPONENT MODULE, AND METHOD OF ASSEMBLING AND INSPECTING WIRE HARNESS

A mounting structure for mounting accessories on a designed interior member in a vehicle compartment includes a plurality of mounting portions. Each of the mounting portions includes a non-contact type power sending terminal and a vehicle-side antenna. The mounting portion transmits power from the battery of the vehicle via the non-contact type power sending terminal, and further transmits a multiplex signal that includes all the control signals required for controlling a plurality of accessories via the vehicle-side antenna. A user can mount an accessory arbitrarily selected from the plurality of accessories on any of the mounting portions without newly installing the required wiring, and therefore readily replace the accessories mounted on the mounting portions.

Mounting structure including communication system for transmitting multiplex control signal to vehicle electrical devices

The present invention provides a vehicle air-conditioning module wherein the surface thereof opposed to the mounting surface of an instrument panel includes at least one electrical component connector which is to be connected directly with the connector of the corresponding one of electrical components through a mount opening formed through the mounting surface of the instrument panel. The present invention also provides another vehicle air-conditioning module comprising an air-conditioner body mounted on the inner wall of a dash panel partitioning between a passenger room and an engine room, an electrical connection box mounted on the top of the air-conditioner body, a first connector mounted in a through-aperture formed in the dash panel and electrically connected with an engine room wire harness, and a second connector mounted on the surface of the electrical connection box opposed to the engine room and electrically connected with the corresponding one of electronic parts in the electrical connection box while fitting to the first connector.

Vehicle air-conditioning module

A method of manufacturing a material for a magnesium alloy member, characterized in that the method comprises the steps of: heating a solid-liquid coexistent magnesium alloy up to a temperature in the range of from the solidus temperature or more to the liquidus temperature thereof or less; homogeneously dispersing carbon fibers into the solid-liquid coexistent magnesium alloy, wherein the carbon fibers have been cut into arbitrary lengths or powdered and have not been subjected to surface treatment; and then cooling the magnesium alloy.

Production method for magnesium alloy member

A rocket fairing mounted on a forward section of a rocket body included in a rocket comprises a first structure formed on the fairing-base side, and including a first side wall defining a first storage space for storing a first payload; and a second structure formed on the fairing-forward side, and including a second side wall defining a second storage space for storing a second payload. The first side wall has a plurality of first side wall segments capable of being separated from each other along a plane including the longitudinal axis of the fairing and of being turned away from the first payload when releasing the first payload from the first storage space. The second side wall has a plurality of second side wall segments capable of being separated from each other along a plane including the longitudinal axis of the fairing and of being turned away from the second payload when releasing the second payload from the second storage space.

Rocket fairing and method of opening the same

A vehicular use power distribution apparatus includes a battery mounted in a vehicle; a main control means connected directly to the battery; a first switch means connected to the battery; a power feed line for loads connected to the first switch means and supplying power to loads mounted in the vehicle; a second switch means connected to the battery; a power feed line for control means connected to the second switch means and controlling the loads; and a sub control means connected to the power feed line for control means. In a first state, the main control means sets the first switch means and the second switch means to a connection state so as to supply power from the battery to the power feed line for loads and the power feed line for control means. When there is not change in first and second mode switching signals within a first predetermined time after a change of first mode switching signal, the main control means sets the first switch means to a non-connection state to set a second state where the supply of power to the power feed line for loads is stopped. After a second predetermined time has passed in the second state, the main control means sets the second switch means to a non-connection state to set a third state where the supply of power to the power feed line for loads is stopped.

Vehicular use power distribution apparatus and vehicular use power

A vehicular use power feed apparatus comprising a battery and a plurality of power distribution units connected in a loop via power feed lines. Each power distribution unit has a current monitoring circuit, a current amount determination circuit, and a current direction determination circuit, detects the direction of current and magnitude of current flowing through the power feed line, and thereby detects an occurrence of a short-circuit. A control unit exchanges information regarding occurrence of short-circuits with adjoining power distribution units via a multiplex signal transmission unit so as to pinpoint the trouble point. The control unit operates the relay switch circuits on the two sides to break the connection so as to isolate the trouble point in cooperation with the control unit of the adjoining power distribution unit. The other relay switch circuit is operated to establish a connection so as to establish a new power feed line.

Vehicular use power feed apparatus

A multiplex transmission apparatus, having a communication control circuit for carrying out transmit-receive control of a frame of data transmitted through a bus, and an output port for outputting data in frame received by the communication control circuit. The multiplex transmission apparatus is operated by a power supply voltage supplied from a power supply circuit to perform data communication with another multiplex transmission apparatus via a bus. First and second low voltage detection circuits, when detecting preset voltage values V.sub.L and V.sub.R of a power supply voltage, reset the communication control circuit and the output port. This multiplex transmission apparatus keeps the output of the output port in a normal condition despite relatively small variations in the power supply voltage (i,e., where V.sub.L .gtoreq.power supply voltage&gt;V.sub.R).

Multiple transmission apparatus

A multiplex transmission apparatus includes a communication control circuit, which monitors data output from an output port and which changes the state of the output port to a predetermined specific state when at least part of the monitored data fails to show a predetermined periodic change with respect to corresponding data previously output, and is operated by a power supply voltage applied thereto from a power circuit to carry out data communications with other multiplex transmission apparatuses. A communication IC maintains the operating state of or resets the output port and the communication control circuit of the multiplex transmission apparatus in accordance with the result of detection by a low-voltage detecting circuit, and a gate circuit inhibits the output port from being changed to the specific state by a timer IC when low voltage is detected or during sleep mode.

Multiplex transmission apparatus

A multiplex transmission system includes a plurality of multiplex nodes interconnected by a common multiplex transmission line. Data frames are transmitted among the multiplex nodes through the multiplex transmission line. A data frame transmitted from a sending multiplex node includes a data area which is divided into subdivided areas in accordance with data transmitted therefrom and data transmitted from receiving multiplex nodes which send data in response to a send request, in accordance with the number of data pieces or the number of bits, and the receiving nodes send data to respective subdivided areas in a predetermined order, to thereby carry out a data transmission. Accordingly, the sending multiplex node can simultaneously collect data from the receiving multiplex nodes which are functionally subordinate. When any of the receiving multiplex nodes fails to return an ACK signal, the sending multiplex node retransmits the data frame.

Multiplex transmission system having plurality of nodes and common

When a message is transmitted, frame by frame, from any one (10) of a plurality of multiplex nodes to a common multiplex bus (MB) to which the multiplex nodes are connected, each of the multiplex nodes (20 and 30) determines that transmission of a frame therefrom is allowed when it detects a transmission permission signal (b, b') added to the frame after detection of and idle state of the multiplex bus, and starts transmitting a message data frame. This makes it possible to properly implement priority-based control according to the priority levels of the data frames irrespectively of variations in the reference clocks of the multiplex nodes. Further, receiving multiplex nodes perform frame synchronization at the rise of a special code (a) of a start code (SOM) of a message data frame, and then perform re-synchronization at the rise of a special bit pattern (b') which includes a passive bit and a dominant bit. This prevents synchronization from being deviated and bit errors resulting from deviated synchronization, thus leading to higher reliability of multiplex transmission.

Multiplex transmission method and a synchronizing method in multiplex

Growing community of inventors

Hiratsuka, Japan

Yutaka Matsuda