Otsuka Kagaku Kabushiki Kaisha

Otsuka Chemical Co., Ltd.

Meiji Seika Kaisha, Ltd.

Taiho Pharmaceutical Company Limited

Meiji Seika Pharma Co., Ltd.

Yutaka Kameyama

Hideo Tanaka

Michio Sasaoka

Sigeru Torii

Takashi Shiroi

Masatoshi Taniguchi

Ryo Kikuchi

Shigeru Torii

Isao Wada

Mitio Sasaoka

Daisuke Suzuki

Yoichi Nishioka

Shigemitsu Nagao

Takae Yamada

Yasuhisa Amano

Norio Saito

Yoshihisa Tokumaru

Seiryu Uto

Koichi Sorajo

Masahiro Ito

Manabu Kuroboshi

Yoshiko Seo

Dal Soo Suh

Nori Saito

Syoichi Tateyama

Takashi Moriyoshi

Kouichi Sorajo

Yasuhiro Uosaki

The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and Xrepresents a halogen atom; wherein R and Xare the same as above, and Xrepresents a halogen atom;

Method for producing 6-hydroxyethylpenam compound

A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto. 

Process for production of 3-alkenylcephem compounds

A 3-alkenylcephem compound of the formula (1) wherein Ris benzyl or phenoxymethyl, R, Rand Rare alike or different and are each a hydrogen atom, Calkyl, Ccycloalkyl or aryl Calkyl substituted or unsubstituted with Calkyl, Rand R, when taken together, form a group &#x2014;(CH)X(CH)&#x2014; substituted or unsubstituted with Calkyl at an optional position, X is an oxygen atom or group &#x2014;N(R)&#x2014;, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, Ris a hydrogen atom or Calkyl.

3-alkenylcephem compounds and process for production thereof

The present invention provides 2&#x3b2;-chloromethyl-2&#x3b1;-methylpenam-3&#x3b1;-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.

Penicillin crystals and process for producing the same

The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.

Processes for producing oxide with higher oxidation than alcohol

A 3-cephem derivative crystal which is a clathrate compound comprising p-methoxybenzyl ester of 7-phenylacetamide-3-formyl-3-cephem-4-carboxylic acid and dimethylformamide and a process for preparing the 3-cephem derivative crystal.

3-cephem derivative crystal

Process for producing oxide with higher oxidation than alcohol

Process for the preparation of cephem compounds

Process for producing 3-cephem compounds

Process for preparation of 3-cephem compound

Process for producing 3-alkenylcephem compounds

A process for preparing a &bgr;-hydroxyester comprising reducing a &bgr;-keto ester in the presence of a salt of ammonium borohydride.

Preparation of &bgr;-hydroxy esters using ammonium borohydrides

The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up to &minus;0.3 (V/SCE) in an amount of at least one mole per mole of the cephem compound and with a metal compound having a higher standard oxidation reduction potential than the metal and in an amount of 0.001 to 10 moles per mole of the cephem compound and wherein X is a halogen atom, lower alkylsulfonyloxy, trifluoromethanesulfonyloxy, trichloromethanesulfonyloxy, arylsulfonyloxy, toluenesulfonyloxy, or halogenated sulfonyloxy

Process for producing exo-methylenepenam compounds

The present invention provides a process for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a &bgr;-lactam halide compound represented by the general formula (2) is subjected to an electroreduction process to obtain the exo-methylenepenam compound.

Process for preparing beta lactam compound

A process for preparing an allenyl .beta.-lactam compound represented by the formula (4), characterized by reacting the hydroxyl group of a .beta.-lactam compound represented by the formula (1) with a reactive functional group derivative of sulfonic acid represented by the formula (2) to convert the compound of the formula (1) to a .beta.-lactam compound represented by the formula (3), thereafter reacting the resulting .beta.-lactam compound with a basic anion exchange resin of the type having a tertiary organic base fixed to the resin and isolating the resulting allenyl .beta.-lactam compound of the formula (4) from the reaction mixture ##STR1##

Process for preparing .beta.-lactam derivatives

Growing community of inventors

Tokushima, Japan

Yutaka Kameyama