Massachusetts Institute of Technology

Sankyo Company, Limited

Daiichi Sankyo Company, Limited

Yutaka Ikeuchi

Hisaki Kajino

Timothy F Jamison

Hiroshi Miyamoto

Rei Okazaki

Eiji Numagami

The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.

Epoxidation catalysts

It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I). [Formula 1] 

Crystalline forms of thiazolidinedione compound and its manufacturing method

A compound having the following formula (III) wherein Ris hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.

Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same

A method for preparing a compound having the following formula (I) by reducing a nitro group of the following formula (III) followed by carrying out an intramolecular dehydration condensation, wherein Ris hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen.

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Kanagawa, Japan

Yutaka Ikeuchi