Daiichi Pharmaceutical Co., Ltd.

Sumitomo Chemical Company, Limited

Yusuke Yukimoto

Nobushige Itaya

Youichi Kimura

Katsuhiro Kawakami

Toshifumi Akiba

Shinji Kamihara

Mikio Sasaki

Ryuhei Wakita

Keiji Uchiyama

Tazuo Uemura

Tsutomu Ebata

Takanobu Ikeya

Norimasa Mikata

Hirofumi Kawanishi

Takashi Namba

Asako Kubo

Selective dehalogenation process

A process for producing a 2-fluorocyclopropane-carboxylic acid of formula �I! ##STR1## by reducing a 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! ##STR2## the reduction being carried out by developing a Raney nickel alloy in the presence of the 2-halo-2-fluorocyclo-propanecarboxylic acid of formula �II!, or by contacting the 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! with hydrogen in an aqueous solvent using a Raney nickel catalyst.

Process for producing 2-fluorocyclopropancecarboxlic acid

A method for selectively obtaining any one of an anhydrate, a 1/2 hydrate, a 1 hydrate, and a 3/2 hydrate of 7-�(7-(S)-amino-5-azaspiro�2.4!heptan-5-yl!-8-chloro-6-fluoro-1-�(1R,2S)-2 -fluorocyclopropyl!-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is disclosed, comprising treating the compound in an aqueous solvent or water or recrystallizing the compound from an aqueous solvent or water.

Crystals of antimicrobial compound

Growing community of inventors

Tokyo, Japan

Yusuke Yukimoto