Hiroshima University

Hiroshima Industrial Promotion Organization

Kojun Japan Co., Ltd.

Yusuke Yamashita

Yoshio Tsujino

Haruo Matsuda

Shuichi Furusawa

Hiroyuki Horiuchi

Seiyu Harada

Atsushi Yamatsu

Jiyeong An

Mikiharu Nakano

Bumbu Masutani

Masaki Nishimoto

Shuichi c/o Hiroshima University Furusawa

Mikiharu c/o Hiroshima University Nakano

Hiroyuki c/o Hiroshima University Horiuchi

Haruo c/o Hiroshima University Matsuda

The present invention provides A PPAR&#x3b3; activator comprising a butenolide compound represented by the formula (1) or a pharmaceutically acceptable salt thereof: wherein Rrepresents a hydrogen atom, a phosphate group, a fatty acid group, an alkyl group having 1 to 4 carbon atoms and optionally having a substituent or a sugar residue optionally having a substituent, and Rrepresents a phenyl group, a methylphenyl group, a dimethylphenyl group, an ethylphenyl group, a benzyl group, a methylbenzyl group, a dimethylbenzyl group, an ethylbenzyl group, a phenethyl group, a methylphenethyl group, a dimethylphenethyl group, or an ethylphenethyl group.

PPAR-gamma activator

A chicken embryonic stem cell is established, which stably has pluripotency and an ability of being differentiated into a germ cell. For evaluating on whether or not the chicken embryonic stem cell can be applied to genetic modification technique, detection is made on a protein which serves as an indicator of the ability of being differentiated into a germ cell. This provides (i) a chicken embryonic stem cell applicable to genetic modification technique and (ii) a method for evaluation of the chicken embryonic stem cell.

Method of determining chicken embryonic stem cells

Growing community of inventors

Kyoto, Japan

Yusuke Yamashita