Olympus Corporation

Stanley Electric Co., Ltd

Dow Global Technolgoies LLC

The Dow Chemical Company

Yusuke Yamashita

Tatsuo Nakata

Yasuhiro Ono

Yoichi Shimoda

Kenji Takano

Toshiyuki Hattori

Hisao Kitagawa

Yasunari Matsukawa

Kaoru Ohba

Takashi Masudo

Ryo Ishibashi

Osamu Kishizaki

Shinnosuke Abe

Masonori Iida

Hiroshi Hirayama

Junichi Okada

Akinori Araya

Makio Ueno

Mitsuhiro Nakano

Masaharu Tomioka

Kei Tsuyuki

Methods for the removal of ionic contaminants from a hydrophilic organic solvent by a mixed bed of ion exchange resins are described. A mixed bed of ion exchange resins with gel-type strong-acid cationic ion exchange resin with a specific moisture holding capacity and gel-type anionic ion exchange resin is used in some embodiments of such methods.

Purification process for hydrophilic organic solvent

A light-emitting device includes a substrate, an electrode, a light-emitting element, a variable light absorbing layer, and a sealing body. The electrode is formed on the substrate. The light-emitting element is disposed on the substrate and electrically connected to the electrode. The variable light absorbing layer is formed so as to cover the electrode on the substrate. The variable light absorbing layer contains a plurality of metal oxide particles that change a light absorption property by irradiation with an ultraviolet light. The sealing body is formed on the substrate so as to seal the light-emitting element. The sealing body has translucency to a light emitted from the light-emitting element.

Light-emitting device

A light-emitting device having high output and high contrast with simple configuration is provided. The light-emitting device includes a substrate, a light-emitting element disposed on the substrate, a light-transmitting member disposed on the light-emitting element, and a covering body disposed on the substrate so as to surround the light-transmitting member and cover a side surface of the light-transmitting member. The covering body has a particle group including a plurality of metal oxide particles having a light scattering property and dispersed in the covering body, and the metal oxide particles existing in the vicinity of the side surface of the covering body have a portion having a bandgap smaller than that of other portions in each particle.

Light-emitting device having covering body for supressing emission of stray light from side surfaces thereof, and light-emitting device module

Methods for the removal of ionic contaminants from hydrolysable organic solvent by ion exchange resins are described. A mixed bed of ion exchange resin with cationic ion exchange resin and weak-base anionic ion exchange resin is used in such methods.

Purification process for hydrolysable organic solvent

A light-emitting device includes a substrate, a light-emitting element disposed on the substrate, a light transmitting member disposed on the light-emitting element, and a covering body disposed on the substrate. The covering body covers a side surface of the light transmitting member and has an exposed upper surface. A particle group composed of a plurality of particles is dispersed in the covering body. The particle group includes a plurality of titanium oxide particles or zinc oxide particles dispersed in a vicinity of an upper surface of the covering body and each having a portion having a narrower band gap than in other portions of the particle.

A fixed region at an outer periphery or an inner periphery of a sample that has a three-dimensional structure is selectively analyzed with accuracy. Provided is an observation system including a CPU that recognizes the 3D shape of an observation target, such as a spheroid, from a 3D image of cells, that sets a 3D mask of which the radial distance from a circumscribed surface of the recognized 3D shape is fixed over the entire region of the circumscribed surface and of which the shape is similar to the circumscribed surface, and that identifies a cell contained inside the set 3D mask.

Observation system

Visual observation of morphological features of a cell group or individual cells acquired in 3D image data is facilitated, thus improving observation accuracy. Provided is an image processing device that generates, on the basis of a plurality of 2D images acquired by a microscope at different focus positions on a cell clump, 3D images of respective cells constituting the cell clump, that processes the generated 3D images and analyzes feature amounts on the basis of at least one measurement parameter, that displays analysis results in a graph, that allows a user to select a region of interest on the displayed graph, and that generates, from the 3D images that correspond to the plurality of cells that are included in the selected region of interest, 2D display images each in a plane with reference to an axis that is determined on the basis of a shape feature of the corresponding cell and displays the 2D display images in a list.

Image processing device and microscope system

A sample observation apparatus includes a memory and a main controller. The main controller stores a first number of photoelectrons required in a raw image for generating a super-resolution image. The main controller calculates the number of image data sets to be added together for generating the raw image based on the first number of photoelectrons stored in the memory and a predetermined image acquisition condition, acquires multiple sets of image data of the same region of a sample by repeatedly detecting light from the same region based on the calculated number of image data sets, and generates the raw image by adding together the acquired multiple sets of image data of the same region.

Sample observation apparatus and method for generating observation image of sample

A microscope system includes a scanner that scans laser light emitted from a continuous-wave light source on a specimen, a beam splitter that splits fluorescence from the specimen into a plurality of light paths with the same wavelength, a plurality of PMTs that respectively detect the fluorescence in the light paths and output light intensity signals, and a computer. Each time the laser light is repeatedly scanned by the scanner, the computer acquires, for each of the PMTs, an image dataset of the specimen based on the light intensity signals. The computer combines a plurality of the image datasets for the same area of the specimen and subjects a final combined image dataset to computational processing for enhancing high-frequency components.

Microscope system

Provided is an observation system including: a monitor; a CPU that identifies, in a 3D image including the plurality of cells, the respective cells by assigning labels that differ from one another to the respective cells, that associates three mutually-intersecting cross-sectional images that constitute the 3D image, and that simultaneously displays the cross-sectional images on the monitor; and an input unit with which an operator specifies an arbitrary cell in any of the cross-sectional images displayed on the monitor. The CPU extracts, from the 3D image, the cross-sectional shapes, in the respective cross-sectional images, of the cell specified by using the input unit, on the basis of the labels, associates the extracted cross-sectional shapes of the cell with one another, and displays the extracted cross-sectional shapes in the respective cross-sectional images displayed on the monitor, in a distinguishable manner from the other cells.

A desired observation timing is ensured, and simultaneity of observation among different observation positions is ensured. Provided is a microscope system including an electrically powered stage, a scanner, objective lenses, a revolver, an image-acquisition portion, an autofocus portion, a first storage portion that stores one of the focal positions of the low-magnification objective lens as a reference position, a focal-position setting portion that sets a focal position at which an image is acquired with reference to the reference position for the low-magnification objective lens, an acquisition-position setting portion that sets acquisition positions for partial images, and a map-image generating portion that generates a map image based on the partial images acquired at the set focal position, wherein the autofocus portion detects a focal position of the high-magnification objective lens at an observation position set on the map image with reference to the reference position for the low-magnification objective lens.

Microscope system and method for microscope system

An observation apparatus compares a plurality of image information acquired in a specific time by a plurality of image acquisition methods whose image acquisition timings are different, and includes a timer for counting observation time, and a PMT and a CCD whose image information acquisition timings are different. A storage unit stores different image information, when acquired by the PMT and the CCD, by relating each type of the acquired image information to the observation information counted by the timer. A control unit sets a display standard to associate the different types of image information stored in the storage unit, according to the observation time that has been respectively related to these types of image information, and associates the different types of image information according to the time information, on the basis of the set display standard. A monitor displays the image information associated by the control unit.

Observation apparatus and observation method

A laser scanning microscope includes a culture vessel that accommodates a specimen and is capable of maintaining an interior temperature and humidity thereof, and an optical system space adjacent and optically connected to the culture vessel. The optical system space includes a scanner that two-dimensionally scans ultrashort pulsed laser light across the specimen; an objective lens that focuses the scanned ultrashort pulsed laser light on the specimen and collects light coming from the specimen; a dichroic mirror, disposed between the scanner and the objective lens, that splits off the light coming from the specimen from the laser light; a photodetector that detects the split-off light coming from the specimen; and an outer cover, provided so as to surround the optical system space, that blocks light coming from outside the optical system space.

Laser scanning microscope

A microscope system comprises a microscope including a motorized stage on which is mounted a container containing a specimen and which can adjust the position of the container, a scanner scanning laser light radiated onto the specimen, an objective lens focusing the scanned laser light, an image-acquisition unit acquiring a specimen image by detecting fluorescence produced in the specimen, and a dark box containing these components; a storage unit storing the mounting position of the container on the motorized stage; an image-acquisition-position setting unit setting acquisition positions of partial images of the inside of the container, on the basis of the stored mounting position of the container; a control section controlling the microscope so as to acquire the partial images for each container on the basis of the set acquisition positions; and a map-image generating section arranging the partial images to generate a map image.

To provide a laser scanning microscope including a laser beam source for stimulation that emits a laser beam for stimulation for applying photostimulation to a sample, a scanner that performs scanning with the laser beam for stimulation, a control device that controls the scanner, and an objective lens that condenses the laser beam for stimulation used for scanning by the scanner to the sample. The scanner has at least one acoustooptic device arranged on an optical path of the laser beam for stimulation. The control device determines a plurality of frequencies on the basis of the position and the range of a photostimulation region, and simultaneously applies the high-frequency signals of the determined plurality of frequencies to a vibrator attached to the acoustooptic device.

Growing community of inventors

Tokyo, Japan

Yusuke Yamashita