Shionogi Company Limited

Kubota Corporation

Hokkaido University

Fuso Pharmaceutical Industries, Ltd.

Intermune, Inc.

Other

Panasonic Intellectual Property Corporation of America

Navitime Japan Co., Ltd.

Yusuke Suzuki

Toyohiko Takeda

Teruo Sakamoto

Yoshio Hamashima

Keiichi Yamamoto

Kyozo Kawata

Hiroshi Tahara

Tetsuya Kosaka

Yasuhiko Suzuki

Yoshihiro Furuya

Kyoji Minami

Toshiro Fujii

Masanori Tujikawa

Nobuyuki Okabe

Hiroshi Tanaka

Shin Kikuchi

Hiroki Oso

Keisuke Onishi

Yoshitaka Tomoda

Gakuji Kiyonaka

Yuzuru Kitahara

Yoshinobu Odawara

Toshimasa Takaki

Wataru Iwanaga

Mitsugu Okuda

Yasushi Takagishi

Hiroyasu Terazawa

Nagayoshi Myo

Satoshi Sakuma

Takahiro Kajihara

Hidekazu Shodai

Kazuhiro Shima

Kinzaburo Noda

Noboru Nagafuji

Seiichi Muroya

Tomohiro Ninomiya

Yongchol Lee

Kazumichi Matsuishi

Takayuki Tsukada

Moe Yoshida

Toshio Nakanishi

Hisayoshi Kato

Takashi Hayashi

Naoya Sakurai

Koji Sato

Hitoshi Kadota

Shuichi Matsuda

Takashi Kushigemachi

Takumi Fukuda

Hidekazu Syodai

Chisato Nakajima

Noboru Nagafuzi

Ikuo Tanai

A threshold value calculation device includes: a device state acquirer that acquires a device state of a first device provided in a facility in which a home network is installed during a first period; an occupancy state determiner that determines an occupancy state by people in the facility during the first period based on information acquired from a second device in the facility; a communication log collector that collects a communication log; and a learner that calculates a threshold value for the communication transmitted and received by the first device during a second period that is a period after the first period. The learner calculates the threshold value for each of combinations of one or more states of the first device and one or more states of the people.

Threshold value calculation device, anomaly detection device, threshold value calculation method, and anomaly detection method

A device with an adjustment bolt includes a bolt attachment wall, an adjustment bolt screwed with an internal thread hole of the bolt attachment wall, a locknut screwed with the adjustment bolt, a cover that surrounds the adjustment bolt and the locknut, and a stopper unit that prevents removal of the cover from the locknut. The stopper unit includes an inner circumference groove of the cover fitted around a C-shaped retaining ring, and an external circumference groove of the locknut fitting within the retaining ring. The external circumference groove includes a first groove portion having a large-diameter groove bottom that restricts contraction and removal of the retaining ring fitted within the inner circumference groove, and a second groove portion provided continuously for the first groove portion and having a small-diameter groove bottom that allows contraction and removal of the retaining ring fitted within the inner circumference groove.

Device with adjustment bolt

An engine includes an engine body, a DPF case therein, high pressure and low pressure EGR paths, and a supercharger. The high pressure EGR path is between exhaust and intake manifolds. An exhaust gas discharge path extends from the DPF case. An intake pipe extends from the supercharger air compressor. The low pressure EGR path is between the exhaust gas discharge path of the DPF case and the intake pipe. The low pressure EGR path includes a low pressure EGR cooler. An extending direction of a crankshaft defines a longitudinal direction. A flywheel exists on a rear side. A width direction of the engine body defines a lateral direction. The low pressure EGR path includes a rear path portion extending along a rear side of the engine body, and a side path portion extending along a lateral side of the engine body on a side close to the exhaust manifold.

Engine

A tablet characterized by comprising 5-methyl-1-phenyl-2-(1H)-pyridone as the main ingredient and, based on the main ingredient, 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, 0.5 to 5 wt. % lubricant, 2 to 6 wt. % coating basis, and 0.05 to 3 wt. % light-shielding agent, wherein the odor or bitterness of the 5-methyl-1-phenyl-2-(1H)-pyridone is masked and the light stability is improved.

Pharmaceutical composition containing as an active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone

The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.

Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof

An engine has an exhaust gas treatment apparatus attached thereto, wherein an exhaust pipe can be prevented from being damaged by a vibration of the engine body. An exhaust gas treatment apparatus is supported by an engine body and the engine body and the exhaust gas treatment apparatus communicate with each other through an exhaust pipe. The casing of the exhaust gas treatment apparatus consists of a plurality of casing units separable from each other. Connection flanges are disposed in respective end portions of the casing units. The casing units are coupled together by a connection of the connection flanges, and the exhaust gas treatment apparatus is supported by the engine body through the connection flanges.

Engine with exhaust gas treatment apparatus

The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired drug resistance gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.

Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof

An object of the present invention is to provide an engine having an exhaust gas treatment apparatus attached thereto, wherein an exhaust pipecan be prevented from being damaged by a vibration of the engine body. To achieve the object, in the engine having the exhaust gas treatment apparatus attached thereto in which an exhaust gas treatment apparatusis supported by an engine bodyand the engine bodyand the exhaust gas treatment apparatuscommunicate with each other through an exhaust pipe, the casing of the exhaust gas treatment apparatus consists of a plurality of casing units, andseparable from each other, connection flanges, andare disposed in respective end portions of the casing units, and, the casing units, andare coupled together by a connection of the connection flanges, and, and the exhaust gas treatment apparatusis supported by the engine bodythrough the connection flanges, and

As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.

Protein substance having triple helix structure and manufacturing method therefor

Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient

The present invention provides a method for preparation of a pharmaceutical composition which comprises suspending a hydrophobic medical compound without generating foams. The present inventors have directed attention to properties of a hydrophobic medical compound and found a method for preparation of a pharmaceutical composition which comprises suspending and dispersing a basic hydrophobic medical compound, and neutralizing with a basic aqueous solution.

Process for producing medicinal composition of basic hydrophobic medicinal compound

The present invention relates to a process for producing a spherical particle comprising an aggregate of particles containing at least 95% of a water-soluble single substance having a viscosity of 10 mPa.s or less as determined in the form of a saturated aqueous solution, the process comprising: preparing moist spherical particles of the single substance by charging, as cores, crystalline particles or granulated particles of the single substance on a rotary disc in a processing vessel of a centrifugal tumbling granulating apparatus, wherein the granulated particles are prepared by granulating a powder of the single substance, and dispersing over the cores a powder of the single substance and simultaneously spraying on the cores a liquid such as water or the like while supplying slit air to provide a fluidized condition; and then fixation treating the moist spherical particles by drying them while spraying an aqueous solution of the single substance or the like on the spherical particles in a fluidized bed apparatus; to the spherical particle produced by the process; and to a pharmaceutical preparation and a food containing the spherical particle.

Spherical single-substance particles, medicines and foodstuffs containing the particles, and method of production thereof

A sustained-release preparation which can release a highly water-soluble medicinally active ingredient over a long time and a process for the production thereof are provided. The preparation has a sustained-releasing layer formed by heating and melting a layer composed of both an aqueous ethylcellulose latex containing a plasticizer and a wax to miscibilize them.

Sustained-release preparation utilizing thermal change and process for the production thereof

Gelatin capsule having adjusted water activity

Growing community of inventors

Osaka, Japan

Yusuke Suzuki