Ube Industries, Inc.

Ube Corporation

Yusuke Shiraishi

Tomio Kimura

Masahiro Kojima

Shigeru Ushiyama

Satoshi Umezaki

Noriaki Iwase

Shigeyuki Kono

Ken-ichi Komori

Hidetoshi Sunamoto

Yasuhiro Aga

Koji Ito

Yasunori Tokunaga

Sayaka Ogi

Haruka Yamada

Takashi Matsushita

Kazuhiro Onuma

Tetsuo Kawaguchi

Makoto Okudo

Masaaki Matoyama

Masaaki Ito

Hiroyoshi Kawada

Masaru Shinohara

Akishi Ninomiya

Hayato Nishiyama

Kenji Yoneda

Tomoko Kanda

Naoya Kinoshita

The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: Aand Aeach independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links Ato A] or a pharmaceutically acceptable salt thereof.

Double-headed protease inhibitor

The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Substituted guanidine compounds

Methods of producing a compound represented by formula (I) or a pharmacologically acceptable salt thereof include: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Substituted dihydropyrrolopyrazole compound

The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a Calkyl group or the like; and R, Rand Reach independently represent an optionally substituted linear or branched Calkyl group. 

Substituted dihydropyrrolopyrazole derivative

The present invention provides a compound of general formula (I) (wherein, R, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Substituted guanidine derivatives

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Growing community of inventors

Ube, Japan

Yusuke Shiraishi