Arqule, Inc.

Renesas Electronics Corporation

Daiichi Sankyo Company, Limited

Showa Denko K.k.

The University of Tokyo

Jfe Steel Corporation

Japan Polyethylene Corporation

Nabtesco Automotive Corporation

Yusuke Ota

Jean-Marc Lapierre

Kiyoshi Nakayama

Hiroaki Inagaki

Sudharshan Eathiraj

Takayuki Momose

Tomoyuki Tsunemi

Takeshi Masuda

Kensuke Nakamura

Brian Schwartz

Hiroaki Uchida

Nivedita Namdev

Takashi Nakada

Shinji Ashida

Mitsuhiro Iwamoto

Narihiro Toda

Daisuke Okajima

Ichiro Hayakawa

Hirofumi Hamada

Tomoko Terauchi

Masaki Meguro

Fuminao Doi

Naoya Harada

Michiaki Sugiyama

Shingo Ito

Yoshikuni Okumura

Kyoko Nozaki

Fukumi Shimizu

Toshikazu Ishikawa

Junichi Kuroda

Mikako Okada

Hiroyuki Shimizu

Ichiro Minato

Manish Tandon

Shinichi Kitamura

Craig G Bates

Yoshihiro Shibata

Kohei Kurihara

Minoru Kobayashi

Masahiro Ota

Ken Sakai

Takashi Odagiri

Tomoya Nishihara

Nobushige Matsuie

Masafumi Koyano

The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

Methods of treating a tumor by administering a claudin-6 (CLDN6) or CLDN9 antibody-pyrrolobenzodiazepine derivative conjugate

Provided are novel antibody-pyrrolodiazepine derivative and novel antibody-pyrrolodiazepine derivative conjugates, as well as methods of using the same, and a novel CLDN6 and/or CLDN9 antibody. The disclosed compounds are of the class of alkyl benzene sulfonyl ureas, useful as oral anti-diabetics, and include substituted benzo[e]pyrrolo[1,2-α][1,4]diazepine.

Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines

A method of annealing a steel sheet in an annealing furnace, including: supporting and conveying a steel sheet with hearth rolls; and supporting and conveying the steel sheet with a full-ceramic hearth roll as a hearth roll located in an area where a furnace temperature is equal to or higher than 950&#xb0; C., wherein a main constituent of the full-ceramic hearth roll is silicon nitride with use of an Al&#x2014;Y-based sintering aid.

Steel sheet annealing method and steel sheet annealing furnace

A novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines represented by the [Formula 24], [Formula 25], [Formula 26], and/or [Formula 27].

Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-&#x3b1;][1,4]diazepines

Antibody-pyrrolobenzodiazepine derivative conjugate and method of use thereof for treating a tumor

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Amino-pyrrolopyrimidinone compounds and methods of use thereof

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof

The present invention relates to a method for producing a copolymer of ethylene and a polar group-containing olefin using as a catalyst a metal complex of group 10 elements having a structure represented by formula (C4) and (C5) (in the formula, 'Men' represents a menthyl group and 'Me' represents a methyl group). The method of the present invention makes it possible to produce a polar group-containing olefin polymer available for various applications, as being a high molecular weight body, which has been difficult to produce, and to produce the polymer in a molecular weight range such that the polymer has good moldability.

Method for producing polar group-containing olefin polymer

A compressed air drying device includes a support base including an inlet of compressed air from a compressor, an outlet of the compressed air, and a discharge port of oil and water. The discharge port includes a drain valve device and a drying container. The container is filled with desiccant and is installed in the support base. In a loading operation, the compressed air drying device causes the desiccant to dry the compressed air introduced through the inlet and discharges the dried compressed air through the outlet. In an unloading operation, the compressed air drying device causes the compressed air to pass through the container to discharge oil and water from the discharge port. A glass fiber filter is provided at one or more of a position upstream of the desiccant and a position downstream of the desiccant in a flow of the compressed air during the loading operation.

Compressed air drying device

The present invention relates to a method for producing a homopolymer of olefin represented by formula (1): CH&#x2550;CHR(Ris a hydrogen atom or hydrocarbon group having 1 to 20 carbon atoms) or a copolymer of two or more thereof or a method for producing a copolymer of olefin represented by formula (1) with olefin containing a polar group represented by formula (2): CH&#x2550;CHRR(Ris a hydrogen atom or methyl group, Ris &#x2014;COOR, &#x2014;CN, &#x2014;OCOR, &#x2014;OR, &#x2014;CH&#x2014;OCOR, &#x2014;CHOH, &#x2014;CH&#x2014;N(R)or &#x2014;CH-Hal (R, Rand Hal have the same meanings as stated in the description), using as a catalyst a metal complex of group 10 elements in the periodic system typified by the structure represented by formula 1 ('Men' represents a menthyl group and 'Me' represents a methyl group). The present invention enables the production of high molecular weight polymers of the polar group-containing monomers such as polar group-containing allyl compounds. 

Production method of polar group-containing olefin polymers

The method includes the steps of: providing a lead frame, including providing a concaved part in an upper face of a joint part of a die-pad-support lead of a lead frame for setting down a die pad and a tie-bar; bonding a semiconductor chip to a first principal face of the die pad via an adhesive-member layer; then, setting the lead frame between first and second molding dies having first and second cavities respectively so that the first and second cavities are opposed to each other, and the second principal face of the die pad faces toward the second cavity; and forming first and second resin sealed bodies on the sides of the first and second principal faces of the die pad respectively by resin sealing with the first and second molding dies clamping the tie-bar and a part of the lead frame surrounding the tie-bar.

Method of manufacturing semiconductor device

Growing community of inventors

Tokyo, Japan

Yusuke Ota