Nof Corporation

Daiichi Pharmaceutical Co., Ltd.

Yusuke Ohkawa

Hiroshi Kikuchi

Norio Suzuki

Tohru Yasukohchi

Chika Itoh

Kazuhiro Kubo

Hitoshi Yamauchi

Syunsuke Ohhashi

Miho Takahashi

Hiroshi Daiichi Pharmaceutical Co Ltd Kikuchi

Norio Daiichi Pharmaceutical Co Ltd Suzuki

Miho Daiichi Pharmaceutical Co Ltd Takahashi

Hitoshi Daiichi Pharmaceutical Co Ltd Yamauchi

A solubilizing composition containing (A) at least one oily component selected from esters of oleic acid with alcohols having 1 to 3 carbon atoms and triglycerides of fatty acids having 6 to 12 carbon atoms, (B) a polyoxyethylenesorbitan fatty acid ester, (C) a polyhydric alcohol which is liquid between 15&#xb0; C. and 25&#xb0; C., and (D) one or more acidic phospholipids where the fatty acid constituting an acyl group thereof is selected from saturated fatty acids having 6 to 14 carbon atoms and unsaturated fatty acids having 16 to 18 carbon atoms, which contains 20 to 40% by weight of the component (A), 30 to 45% by weight of the component (B), 15 to 40% by weight of the component (C), and 0.5 to 4% by weight of the component (D), based on 100% by weight of a total amount of the components (A) to (D).

Solubilizing composition

A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, RCO and RCO independently represent an acyl group having 8 to 22 carbon atoms, symbol 'a' independently represents an integer of 0 to 5, symbol 'b' independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1&#x2266;k1&#x2266;(k+2)/2, 0&#x2266;k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.

Phospholipid derivatives and process for the production there

Growing community of inventors

Kanagawa, Japan

Yusuke Ohkawa