Fujifilm Corporation

Yusuke Mochizuki

Ryuta Takegami

Makoto Sawada

Kazuhiro Hasegawa

Kuniyuki Kaminaga

Atsushi Mukai

Kentaro Nakamura

Takeshi Narita

Naohiro Matsunaga

Satoshi Yoneyama

Shigeaki Ohtani

Shigehide Itou

Hiroyuki Noda

Yoichi Hosoya

Kazuki Yamazaki

Motoi Harada

Daisuke Hiraki

Ryo Kogawa

Kenichi Yamamoto

Naruhiko Aono

Yoshiyuki Kamide

Nakamura Kentaro

According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm×30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane including a center plane in a thickness direction of the sandwiched portion of the membrane for immunoisolation, and a part, which is farthest from the horizontal plane, of a residual 20 mm-portion projecting from the flat plate; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein.

Chamber for transplantation and device for transplantation

According to the present invention, there are provided a chamber for transplantation, including a membrane for immunoisolation including a porous membrane at at least part of a boundary between an inside and an outside of the chamber for transplantation, in which the porous membrane contains a polymer and has a layered compact portion where a pore diameter is the smallest within the membrane, a pore diameter continuously increases in a thickness direction from the compact portion toward both one surface A and the other surface B of the porous membrane, a porosity in a vicinity of the surface A is 65% or more, an average pore diameter of the surface A is larger than an average pore diameter of the surface B, and the surface B is disposed on the inside of the chamber for transplantation; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein. In the chamber for transplantation of the present invention, angiogenesis in a recipient is induced and a deterioration in substance permeability is unlikely to occur.

According to the present invention, there are provided a chamber for transplantation which has a high durability, and in which an enclosed biological constituent can be maintained for a long period of time because an interior space thereof is efficiently secured; and a method for manufacturing the chamber for transplantation. The chamber for transplantation includes one or more membranes for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which all of the membranes for immunoisolation include a porous membrane containing a polymer, and a joint portion at which the porous membranes are directly fusion welded to each other is provided. The method for manufacturing a chamber for transplantation includes preparing one or more porous membranes containing a polymer selected from polysulfone and polyethersulfone, bringing one part of the porous membrane into direct contact with another part of the porous membrane, and performing a heat fusion welding of the two parts that are in direct contact with each other at a temperature which is a glass transition temperature of the polymer or higher and lower than a melting point of the polymer.

Chamber for transplantation, method for manufacturing chamber for transplantation, device for transplantation, and method for fusion welding porous membranes

According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm&#xd7;30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane including a center plane in a thickness direction of the sandwiched portion of the membrane for immunoisolation, and a part, which is farthest from the horizontal plane, of a residual 20 mm-portion projecting from the flat plate; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein.

An object of the present invention is to provide a cell transplant device having an ability to induce angiogenesis around the cell transplant device, and a method for manufacturing the same. According to the present invention, a cell transplant device including a cell structure (A) that includes a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure is provided.

Cell transplant device and method of manufacturing the same

Provided are a gas separation membrane which has a resin layer containing a compound having a siloxane bond, in which the resin layer containing a compound having a siloxane bond satisfies Expressions 1 and 2, and at least one of gas permeability or gas separation selectivity is high under high pressure; a method of producing a gas separation membrane; a gas separation membrane module; and a gas separator.0.9&#x2265;&#x2265;0.63&#x2003;&#x2003;Expression 1&#x2265;1.7&#x2003;&#x2003;Expression 2In the expressions, A represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms contained in the resin layer containing a compound having a siloxane bond at a depth of 10 nm from the surface of the resin layer containing a compound having a siloxane bond, and B represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms in the surface of the resin layer containing a compound having a siloxane bond.

Gas separation membrane, method of producing gas separation membrane, gas separation membrane module, and gas separator

According to the present invention, there are provided a membrane for immunoisolation, including: a porous membrane that contains a polymer, in which the porous membrane includes a layered compact portion where a pore diameter is the smallest within the membrane, and a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane; a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation, including the above-described chamber for transplantation enclosing the biological constituent therein. In the membrane for immunoisolation of the present invention which can be manufactured at low costs, a deterioration in substance permeability is unlikely to occur.

Membrane for immunoisolation, chamber for transplantation, and device for transplantation

According to the present invention, there is provided a membrane for immunoisolation, including a porous membrane that contains a polymer, in which Formulas (I) and (II) are satisfied for at least one surface of the porous membrane, B/A&#x2264;0.7 (I) and A&#x2265;0.015 (II) (in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane); a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation includes the above-described chamber for transplantation enclosing the above-described biological constituent therein. The membrane for immunoisolation of the present invention has a high bioaffinity.

A gas separation membrane, the gas separation membrane module, and the gas separation device each have a support, a resin layer, a separation layer, and a protective layer in this order, in which the resin layer includes a compound having a siloxane bond, the protective layer is in direct contact with the separation layer, a composition of the protective layer is different from a composition of the resin layer, the composition of the protective layer is different from a composition of the separation layer, and the separation layer has a maximum value of a silicon atom content of 2 atomic % or less in a composition of a half area on a side of the protective layer in a thickness direction.

Gas separation membrane, gas separation membrane module, and gas separation device

A protective-layer-covered gas separation membrane has a gas separation membrane that satisfies specific conditions such as having a resin layer containing a compound having a siloxane bond, a protective layer located on the resin layer containing a compound having a siloxane bond of the gas separation membrane, and a porous layer on the protective layer. The protective-layer-covered gas separation membrane is produced. A gas separation membrane module and a gas separation apparatus have the protective-layer-covered gas separation membrane.

Protective-layer-covered gas separation membrane, method for producing protective-layer-covered gas separation membrane, gas separation membrane module, and gas separation apparatus

A method for producing a protective-layer-covered gas separation membrane includes forming a gas separation membrane having a resin layer containing a compound having a siloxane bond and satisfying a particular condition by surface oxidation treatment of a resin layer precursor containing a siloxane bond; and providing a protective layer on the resin layer before winding. A protective-layer-covered gas separation membrane is produced by the method for producing a protective-layer-covered gas separation membrane. A gas separation membrane module and a gas separation apparatus are produced by the method for producing a protective-layer-covered gas separation membrane.

Method for producing protective-layer-covered gas separation membrane, protective-layer-covered gas separation membrane, gas separation membrane module, and gas separation apparatus

A gas separation membrane, the gas separation membrane module, and the gas separation device include a first separation layer, and a second separation layer, the first separation layer has an Si/C ratio of 0.3 or less, the Si/C ratio being a ratio of the number of silicon atoms to the number of carbon atoms at the interface of the first separation layer on the second separation layer side, the second separation layer has a maximum value of an F/C ratio of 0.20 or more, the F/C ratio being a ratio of the number of fluorine atoms to the number of carbon atoms, and an Si/C ratio of 0.3 or less in a portion where the F/C ratio is maximum.

Provided are a gas separation membrane which has a resin layer containing a compound having a siloxane bond, in which the resin layer containing a compound having a siloxane bond satisfies Expressions 1 and 2, and at least one of gas permeability or gas separation selectivity is high under high pressure; a method of producing a gas separation membrane; a gas separation membrane module; and a gas separator.0.9&#x2265;&#x2265;0.55&#x2003;&#x2003;Expression 1&#x2265;1.7&#x2003;&#x2003;Expression 2 In the expressions, A represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms contained in the resin layer containing a compound having a siloxane bond at a depth of 10 nm from the surface of the resin layer containing a compound having a siloxane bond, and B represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms in the surface of the resin layer containing a compound having a siloxane bond.

Provided is a gas separation membrane including a support, a separation layer, and a protective layer in this order, in which the separation layer contains inorganic particles, the protective layer contains a resin and inorganic particles having an average particle diameter of 10 nm or greater which is less than 0.34 times the film thickness of the protective layer, and the content of the inorganic particles contained in the protective layer is 40% by mass or less with respect to the content of the resin contained in the protective layer, the gas separation membrane being capable of being made into a spiral type gas separation membrane module while maintaining high permeability; and a gas separation membrane module which uses the gas separation membrane.

Gas separation membrane and gas separation membrane module

An acidic gas separation module including: a perforated hollow central tube; and a layered body that is wound on the perforated hollow central tube and has, in the following order on a porous support: an acidic gas separation layer containing a water-absorbing polymer, a carrier, and water; and a flow channel material with a network structure having a thread intersection portion and an arithmetical surface roughness for a surface contacting the acidic gas separation layer in the thread intersection portion of 35 &#x3bc;m or less. The acidic gas separation module suppresses generation of flocculated water by maintaining the generation of turbulent flow in the flow channel material, effectively suppresses damage to the surface of the acidic gas separation layer by the flow channel material in the winding-on process during manufacture, and exhibits excellent acidic gas separation efficiency.

Growing community of inventors

Kanagawa, Japan

Yusuke Mochizuki