Shionogi Company Limited

Yusuke Ichihashi

Koji Masuda

Naoki Tsuno

Masanao Inagaki

Shinji Suzuki

Akira Yukimasa

Hiroki Yamaguchi

Tatsuhiko Ueno

Motohiro Fujiu

Takatsugu Inoue

Hiromi Kudo

Novel compounds having a D3 receptor antagonistic activity are provided. The compound represented by Formula (I): wherein Ring A is a non-aromatic heterocycle or the like substituted with substituted or unsubstituted aromatic heterocyclyl or the like; Rto Rare each independently a hydrogen atom or the like; n is an integer of 0 to 3; Ring B is a non-aromatic carbocycle or the like; Ris each independently halogen or the like; r is an integer of 0 to 4; -L- is &#x2014;N(R)&#x2014;C(&#x2550;O), or the like; Ris a hydrogen atom or the like; Ris substituted or unsubstituted aromatic heterocyclyl or the like,or a pharmaceutically acceptable salt thereof.

Cyclic compound having dopamine D3 receptor antagonistic effect

The present invention is related to a compound represented by formula (I) wherein &#x2014;X&#x2014; is &#x2014;NH&#x2014; or &#x2014;S&#x2014;; &#x2014;Z&#x2014; is &#x2014;O&#x2014; or &#x2014;S&#x2014;; R, Rand Rare each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; Ris a cyano, substituted or unsubstituted amino, or the like; Ris each independently a halogen; b is 0 or 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

Aromatic heterocyclylamine derivative having TRPV4-inhibiting activity

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Osaka, Japan

Yusuke Ichihashi