Daiichi Sankyo Company, Limited

Exelixis, Inc.

Yusuke Asoh

Kazumasa Aoki

Hiroyuki Tsuruoka

Noriyuki Hayashi

Juri Yoshida

Raju Mohan

Matthew A Williams

John M Nuss

Richard Martin

Yasuo Fukushima

Keiji Saito

Tie-Lin Wang

Shinji Marumoto

Mikio Kato

Masayuki Ebisawa

Tsuyoshi Homma

Toyoki Nishimata

Masatoshi Honzumi

Provided is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonist) action. A compound represented by the following general formula (1): [wherein, Ar which is a partial structure in the general formula (1) represents a phenyl group or a naphthyl group; Rand Rare the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; Rand Rare the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; A represents a single bond, an oxygen atom, or the like; B represents a single bond, a C1-C4 alkanediyl group, or the like; Z represents a carboxyl group or a tetrazolyl group; and m represents an integer of 1 to 3] or a pharmacologically acceptable salt thereof.

Cycloalkylamne derivatives

[Object] A prophylactic or therapeutic agent for a cardiovascular disease is provided. [Means for Resolution] An atropisomer of a compound represented by the following general formula (I): (wherein Ris a C1-C3 alkyl group or a hydroxy-C1-C3 alkyl group; and Ris a hydrogen atom or a C1-C3 alkoxy group).

Atropisomer of pyrrole derivative

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein Rrepresents a C1-C3 alkyl group; Rrepresents a hydroxy-C1-C4 alkyl group and the like; Rrepresents a halogeno group, a halogeno-C1-C3 alkyl group and the like; Rrepresents a hydrogen atom, a halogeno group and the like, &#x2014;Rrepresents a sulfamoyl group or a C1-C3 alkylsulfonyl group; Rrepresents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing. 

1-phenylpyrrole derivatives

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Tokyo, Japan

Yusuke Asoh