Alcon Laboratories, Inc.

Gojo Industries, Inc.

Alcon Manufacturing, Ltd.

Yusuf Ali

Rajni Jani

Ernesto J Castillo

Rajkumar P Bhatia

Alok K Kulshreshtha

Wesley Wehsin Han

Kenneth W Reed

Geoffrey R Owen

Thomas R Dean

Steven Howard Gerson

Ronald A Barnhart

Ruma P Sarkar

Robert E Beck

Mojgan Cline

John G Edwards

Rex C Sport

George R McCarty

This invention relates to an antimicrobial skin sanitizing composition for disinfecting skin, and particularly, hands. The composition contains at least 60 percent of an aliphatic alcohol having from 1 to 4 carbon atoms, from about 0.1 to about 5 weight percent of a thickening agent, and an effective amount of a GRAS or amino acid neutralizer to neutralize the thickening agent.

Skin sanitizing antimicrobial alcoholic compositions

Methods for cleaning soiled contact lenses are disclosed. The methods involve contacting the soiled lens with a cleaning composition comprising carbon dioxide and carbonic acid as cleansing agents. The cleaning compositions do not require abrasive agents such as polymeric beads, nor ocularly irritating agents such as enzymes or surfactants in order to effectively clean proteinaceous and nonproteinaceous deposits from the surface of contact lenses.

Method of cleaning contact lenses using carbon dioxide and carbonic acid

Simple, efficacious, easily manufacturable, convenient to use and cost-effective contact lens care cleaning compositions comprising carbon dioxide and carbonic acid as cleansing agents are disclosed. The compositions do not require abrasive agents such as polymeric beads, nor ocularly irritating agents such as enzymes or surfactants in order to effectively clean proteinaceous and nonproteinaceous deposits from the surface of contact lenses. Also disclosed is a one-step cleaning and disinfecting regimen, whereby an effervescent tablet composition capable of generating carbon dioxide and carbonic acid is dissolved in a disinfecting solution or rinsing/disinfecting/storage solution.

Use of carbon dioxide and carbonic acid to clean contact lenses

Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed.

Process for manufacturing ophthalmic suspensions

Aqueous pharmaceutical compositions containing a synergistic combination of a quinolone and a polystyrene sulfonic acid polymer are described, wherein the compositions are clear solutions which are comfortable and have sustained release. Methods for use of the compositions are also disclosed. This type of formulation is particularly useful with ciprofloxacin-type quinolones by greatly increasing the solubility of these quinolones, making it feasible to have aqueous solutions containing such quinolones at or near physiological pH.

Antibacterial compositions

Stable formulations of positively charged, hydrolytically unstable drug compounds are obtained by adding a sulfated polyvinyl alcohol copolymer to the formulations.

Sulfated polyvinyl alcohol polymers to stabilize pharmaceutical drug

The present invention is directed to topical ophthalmic formulations of carbonic anhydrase inhibitors and polyethoxylated derivatives of castor oil. Methods for using the formulations for treating and controlling glaucoma and ocular hypertension are also disclosed.

Topical ophthalmic carbonic anhydrase inhibitor formulations

Compositions for controlling glaucoma and ocular hypertension are disclosed.

Compositions for treatment of glaucoma

Certain anionic surfactants are used to enhance antimicrobial effectiveness in comfortable, sustained release ophthalmic compositions containing polyelectrolytes, such as carboxyvinyl polymers, polystyrene sulfonic acid polymers and cationic exchange resins, as well as at least one active ingredient.

Use of certain anionic surfactants to enhance antimicrobial

Ophthalmic pharmaceutical vehicles which become viscous on contacting the eye are disclosed. Ophthalmic compositions of the vehicle and a pharmaceutically active drug are also disclosed.

Topical ophthalmic pharmaceutical vehicles

Universal ophthalmic pharmaceutical vehicles which increase in viscosity upon instillation in the eye are disclosed. Ophthalmic compositions of the universal vehicle and a pharmaceutically active drug are also disclosed. In one embodiment, the vehicle gels upon instillation in the eye. In another embodiment, suspension vehicles having superior physical stability are provided.

Disclosed are nonstinging, sustained release ophthalmic formulations. The formulations comprise a cationic drug, an acidic mucomimetic polymer and a polystyrene sulfonic acid polymer. In particular, formulations for the control of intraocular pressure and glaucoma are disclosed. Methods for use of the formulations are also disclosed.

Glaucoma formulations comprising an anionic, polysulfonic acid polymer

A method of preparing aqueous pharmaceutical compositions containing a synergistic combination of trimethoprim and sodium sulfacetamide is described. The method results in a significant improvement in the aqueous solubility of trimethoprim due to a favorable interaction between the trimethoprim and sodium sulfacetamide which is dependent on a mildly acidic pH.

Growing community of inventors

Fort Worth, TX, United States of America

Yusuf Ali