Japan Energy Corporation

Yuso Goto

Yoshiaki Isobe

Osamu Takahashi

Masanori Tobe

Hideharu Sato

Nobuyoshi Chiba

Junko Umezawa

Nobuo Watanabe

Masashi Sasaki

Toshimasa Katagiri

Fumihiro Obara

Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): ##STR1## wherein R.sup.1 is a phenyl group which is unsubstituted or substituted with a substituent or substituents each independently selected from the group consisting of a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group;

Hydroquinone derivative and pharmaceutical use thereof

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): ##STR1## wherein R.sub.1 is H, alkyl or aralkyl;

1-arylpyrimidine derivatives and pharmaceutical use thereof

Purine derivatives shown by general formula [I] or pharmacologically acceptable salts thereof. Suppressants for inflammatory diseases containing an effective ingredient of said purine derivative. ##STR1## (wherein, R represents one group selected from the groups composed of H atom, a straight chain alkyl group having 1-10 carbon atoms, a branched chain alkyl group having 3-10 carbon atoms, an alkyl group having 1-10 carbon atoms substituted with one carboxyl group, 4-carboxybenzyl group and phenethyl group). Above mentioned purine derivatives prevent the tissue damages due to mediators such as active oxygen and TXA.sub.2 in the initial stage of inflammation, and prevent the subsequent aggravation of inflammatory responses due to the adhesion of activated leukocytes to the cells in the lesion, and exhibit efficacy as anti-inflammatory drugs in all stages of inflammatory diseases caused by leukocytes.

Purine derivatives and suppressants for inflammatory diseases

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Toda, Japan

Yuso Goto