Chinese Academy of Sciences

Zhe Jiang Jutai Pharmaceutical Co., Ltd.

Nanjing Changao Pharmaceutical Science & Technology Co., Limited

Yushe Yang

Bin Guo

Wei Li

Xin Liu

Kaixian Chen

Houxing Fan

Lei Tang

Qian Chen

Zhan Li

Tao Xue

Liang Tan

Qunhuan Kou

Chenghui Shi

Shi Ding

Qisheng Xin

Huili He

Ruyun Ji

Yinyong Zhang

Disclosed in the present invention are a thiazolidone spiro pyrimidine trione compound, a preparation method therefor and uses thereof, the compound having a structure represented by formula (I). In the formula, the definitions of the substituents are described in the specification and the claims. The thiazolidone spiro pyrimidine trione compound in the present invention has high in vivo and in vitro antibacterial activity, has better metabolic properties, and is obviously superior to existing compounds of the same kind. 

Thiazolidone spiro pyrimidine trione compound, preparation method therefor and uses thereof

The present disclosure relates to the field of pharmaceutical synthesis, and more particularly, relates to a monocyclic &#x3b2;-lactam-siderophore conjugate as well as a method for synthesizing same and its use in the treatment of bacterial infectious diseases. Provided are a monocyclic &#x3b2;-lactam-siderophore conjugate represented by formula (I) as described herein, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a method for synthesizing same, and a use thereof in treating bacterial infectious diseases.

Monocyclic &#x3b2;-lactam-siderophore conjugate, and preparation method and use thereof

Disclosed are a benzoxazine oxazolidinone compound shown by a general formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a preparation method thereof, and an application thereof in preparing a drug for treating an infectious disease and in particular, an infectious disease caused by multidrug resistant bacteria. 

Benzoxazine oxazolidinone compound, preparation method and application thereof

The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.

Oxazolidone compound, preparing method and application thereof

Novel benzoxazine oxazolidinone compounds, preparation methods and uses thereof are disclosed, which belong to the field of pharmacy. More specifically, novel benzoxazine oxazolidinone compounds represented by the following general formula (I), preparation methods and uses thereof in preparing medicament for treating infectious diseases, especially infectious diseases caused by multi-drug resistant bacteria, are disclosed. 

Benzoxazine oxazolidinone compounds, preparation methods and uses thereof

The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; Rrepresents a hydrogen atom or a Calkyl that can be substituted; Rrepresents a hydrogen atom, a Calkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus. 

Benzopyran compounds, process for preparing the same and their use

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Shanghai, China

Yushe Yang