The Green Cross Corporation

Yusei Shiraga

Tadakazu Suyama

Kazumasa Yokoyama

Chikara Fukaya

Satoshi Funakoshi

Yasuo Ueda

Yoshiro Iga

Yoshio Kagitani

Masakazu Iwai

Toshiaki Akira

Kanemichi Okano

Mamoru Tabata

Hiroshi Fukui

Shigeo Tanaka

Kenji Tanaka

Takao Ohmura

Satoshi Morimoto

Tunetaka Nakajima

Takuji Doi

A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or .dbd.O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.5 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;

Therapeutic and prophylactic agents for peptic ulcer

A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;

Benzodiazepine derivative represented by the following general formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is --COR.sup.4 (R.sup.4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R.sup.2 is a lower alkyl group and R.sup.3 is a hydrogen atom or a lower alkyl group. The above compound is low in toxicity and has an antitumor activity.

1H-pyrrolo-[2,1-C][1,4]benzodiazepine-2-acrylamide compounds having

Physiologically active substances such as antibiotics can preferentially be carried to a morbid part, for example, injured tissue and neoplastic cell proliferation site by administering its complex with fibronectin to repair the morbid part. The complex is prepared by the reaction between the physiologically active substance and the fibronectin with or without intervention of a protein cross-linking agent.

Fibronectin-physiologically active substance complex and method of

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Hyogo, Japan

Yusei Shiraga