Mitsui Toatsu Chemicals, Incorporated

Mect Corporation

Yusaku Ishizuka

Akira Awaya

Hisashi Kobayashi

Hayao Abe

Shoichiro Ozaki

Yutaka Watanabe

Masayoshi Ito

Tomoya Ogawa

Shoji Yoshimura

Masaaki Numata

Yoshitaka Nagai

Makoto Tanaka

Shohei Shibayama

Toshikazu Yamanouchi

A medicament for prevention and remedy of diseases caused by the infection of viruses is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration: pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn or an ester and an amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.

Method of treating disease caused by the infection of virus

Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.

Myoinositol derivatives and preparation process thereof

Medicament for prevention and remedy of diseases of the pancreas and

A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

Sialic acid-bonded octapeptide and preparation thereof

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Yokohama, Japan

Yusaku Ishizuka