Ajinomoto Co., Ltd.

Yury Ivanovich Kozlov

Konstantin Vyacheslavovich Rybak

Ekaterina Aleksandrovna Slivinskaya

Yoshihiko Hara

Elvira Borisovna Voroshilova

Tatyana Viktorovna Leonova

Mikhail Markovich Gusyatiner

Vera Georgievna Doroshenko

Vitaly Grigorievich Paraskevov, Legal Representative

Takuji Ueda

Sakayu Shimizu

Hisashi Yasueda

Tomohiro Kodera

Veronika Aleksandrovna Kotliarova

Makoto Hibi

Natalia Nikolaevna Samsonova

Joanna Yosifovna Katashkina

Akito Chinen

Natalia Yurievna Rushkevich

Ekaterina Alekseevna Savrasova

Marina Evgenievna Sheremet'eva

Tomoko Suzuki

Yoshihiro Usuda

Kazuhiko Matsui

Jun Ogawa

Hiroshi Izui

Sergei Vladimirovich Mashko

Sergey Vasilievich Smirnov

Aleksandra Yurievna Skorokhodova

Elena Vitalievna Klyachko

Valeriy Zavenovich Akhverdian

Vitaly Arkadievich Livshits

Tatyana Abramovna Yampolskaya

Vitaliy Arkadyevich Livshits

Valery Zavenovich Akhverdian

Natalia Pavlovna Zakataeva

Leonid Romanovich Ptitsyn

Irina Borisovna Altman

Larisa Gotlibovna Airikh

Evgeni Moiseevich Khourges

Ekaterina Aleksandrovna Kutukova

Masaru Terashita

Anna Evgenievna Novikova

Lirina Valeryevna Ivanovskaya

Sergei Vlsdimirovich Mashko

Nataliya Vasilyevna Gorshkova

Alla Valentinovna Belaryeva

Yulia Aleksandrovna Ovodova

Sergey Viktorovich Gronsky

Tomoko c/o Ajinomoto Co Inc Suzuki

Hisashi Ajinomoto Co Inc Yasueda

Olga Nikolaevna Mokhova

Yoshihiko Ajinomoto Co Inc Hara

Akito Ajinomoto Co Inc Chinen

Hiroshi Ajinomoto Co Inc Izui

Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5'-inosinic acid are provided which include using a bacterium belonging to the genusor to the genuswherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein fromand the gene encoding it.

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The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.

Use of phosphoketolase for producing useful metabolites

There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.

Method for producing L-amino acids using bacteria of the enterobacteriaceae family

A highly active L-isoleucine dioxygenase fromis provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

Method for producing 4-hydroxy-L-isoleucine

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of a gene coding for sRNA.

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of the ybiV gene.

Method for producing L-amino acids using bacteria of the Enterobacteriaceae family

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to have glycerol kinase in which feedback inhibition by fructose-1,6-bisphosphate is desensitized, thereby having enhanced ability to utilize glycerol.

Method for producing an L-amino acid by fermentation using a bacterium having an enhanced ability to utilize glycerol

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Moscow, Russia

Yury Ivanovich Kozlov