Gilead Sciences, Inc.

Yurong Lai

James G Taylor

Michael L Mitchell

Hongyan Guo

Ana Zurisadai Gonzalez Buenrostro

Xiaochun Han

Gregg M Schwarzwalder

Jamie Geier Bates

Ting Wang

Brian J Kirby

The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Thienopyrimidine derivatives as ACC inhibitors and uses thereof

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Dublin, CA, United States of America

Yurong Lai