Teva Pharmaceutical Industries Limited

Yeda Research and Develpment & Co. Ltd

Yuriy Raizi

Claude Singer

Revital Lifshitz-Liron

Gideon Pilarski

Lilach Hedvati

Ziv Dee-Noor

Revital Ramaty

Sharon Tomer

Shlomit Wizel

Nina Finkelstein

Jeffrey Sterling

Anita Liberman

Yaacov Herzig

Gideon Pilarsky

Sharon Avhar-Maydan

Kobi Chen

Viviana Braude

Istvan Miskolczi

Amihai Eisenstadt

Vladimir Ioffe

Esti Marom

Andras Zekany

Disclosed are enantiomers of amino-phenyl-acetic acid octadec-9-(Z)-enyl ester, and salts thereof, including pharmaceutical compositions, uses and a process for the manufacture thereof.

Enantiomers of amino-phenyl-acetic acid octadec-9-(Z) enyl ester, their salts and their uses

The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chlorohydroxymethyl]sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.

Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole

The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with C-alcohol; and combining the organic phase with an organic base.

Pregabalin free of lactam and a process for preparation thereof

A Pregabalin having a low level of 3-isobutylglutaric acid is provided.

Pregabalin free of isobutylglutaric acid and a process for preparation thereof

Isolated cinacalcet carbamate, processes for the preparation thereof, and processes for the use of cinacalcet carbamate as a reference marker and standard are provided. Also provided are cinacalcet salts substantially free of cinacalcet carbamate, and processes for the preparation thereof.

Purification of cinacalcet

Processes for preparing cinacalcet are provided.

Process for preparing Cinacalcet hydrochloride

Growing community of inventors

Natanya, Israel

Yuriy Raizi