The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin

The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near Dublin

Davies, Anthony

The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth,

Yuri Volkov

Dermot P Kelleher

Igor V Shvets

Vivienne Williams

Dmitriy Kashanin

Anthony Davies

Slobhan Mitchell

Siobhan Mitchell

Dermot Kelleher

Igor Shvets

A device () for housing a scientific sample comprising at least one sample well () and an on-board buffering substance () wherein the onboard buffering substance () at least partly surrounds the sample well (). The on-board buffering substance () may be in the form of a matrix, such as a gel-like matrix. The device () may further comprise an insulating means. Also described is a substance for use in culturing and/or assaying a sample whereby the substance provides atmospheric and thermal buffering. The invention further provides a lid for a single-well or multi-well sample plate, the lid being configured to facilitate delivery of a sample through the lid into a well, and for sealing the well. The lid comprises moveable portions () that have at least one orifice () formed through the moveable portions () such that a conduit is formed by alignment of the orifices () of both the lid portions ().

Substance and a device

Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochipcomprises a microchannelhaving a liquid outlet port, bubble release portand a liquid outlet portwith an associated bubble release port. A multiplicity of tests can be performed often by coating the bore of the microchannelwhich various adhesion mediating proteins or the use of chemoattractants. The assay assemblycomprises a syringe pump feeding the biochip. An inverted microscope, digital cameraand recorderare provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

Method of assaying cellular adhesion with a coated biochip

Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip comprises a microchannel having a liquid outlet port , bubble release port and a liquid outlet port with an associated bubble release port . A multiplicity of tests can be performed often by coating the bore of the microchannel which various adhesion mediating proteins or the use of chemoattractants. The assay assembly comprises a syringe pump feeding the biochip . An inverted microscope , digital camera and recorder are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

Biological assay method

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Dublin, Ireland

Yuri Volkov