Chugai Seiyaku Kabushiki Kaisha

Osaka University

Yuri Teranishi

Tomoyuki Igawa

Hiroyuki Tsunoda

Takeshi Baba

Atsushi Kumanogoh

Ryusuke Omiya

Sachiyo Suzuki

Tetsuhiro Soeda

Kazuki Kato

Hikaru Koga

Kazuki Yamaguchi

As a result of producing ACE910 variants in which various sites of the constant regions were modified, the inventors discovered bispecific antibodies having FVIII mimetic activity higher than that of ACE910. The inventors also identified mutation positions that elevate the FVIII mimetic activity and discovered methods for elevating the FVIII mimetic activity by using the mutations.

Bispecific antibodies which bind blood coagulation factor VIII and have enhanced activity, and methods of use thereof for treating bleeding and associated conditions

Provided is a novel anti-Plexin-A1 agonist antibody that promotes dendritic cell contraction. Also provided is a pharmaceutical composition comprising such an antibody and a pharmaceutically acceptable carrier.

AntiPlexin A1 agonist antibody

Bispecific antibodies whose FIX activation-inhibiting activity is not elevated and whose FVIII cofactor function-substituting activity is elevated have been successfully discovered.

Multispecific antigen-binding molecules having blood coagulation factor VIII (FVIII) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ingredient

Growing community of inventors

Shizuoka, Japan

Yuri Teranishi