Canon Kabushiki Kaisha

Yuri Mizutani

Ichiro Okumura

Jiro Shirakata

Isao Hayashi

Yoshihiro Shigemura

Shin-ichiro Takahama

Shin-Ichiro Takahama

A biochemical reaction cassette comprises: a substrate carrying probes immobilized thereon, the probes being adapted to be specifically bound to a target substance; a reaction space forming member for forming a reaction space with the substrate; an elastic member; and an anchor member for supporting the substrate so as to keep it movable relative to the reaction space forming member by way of the elastic member.

Biochemical reaction cassette and detection apparatus for biochemical reaction cassette

In amplifying a region containing two allelic genes, the polymorphism of one of the allelic genes is positioned at or near the 3' end of an amplification primer, so that the chain would extend only from one of the two primers, one that matches the mutant type nucleotide(s) and one that matches the wild-type nucleotide(s). The other primer is unaffected by the allelic genes but is positioned to include the other allelic gene in the amplicon. The PCR amplifies only the target genomic DNA having one specific allele of the first allelic gene. The technique exploits the fact that the haplotype of the first and the second allelic genes can be determined if the allele of the second allelic gene in the amplicon can be identified. Designing probes with complementary sequences for identifying the two alleles (major and minor) of the second allelic gene, and fixing the probe set on a solid support and hybridizing them with the amplicon to identify the probe that forms a hybrid, are characteristic features of the present invention.

Method of determining the haplotype of multiple allelic genes

A first and second electrostatic image code is located outside a developing zone. A transfer belt provided with an electrostatic image recording track capable to transfer the electrostatic code between the first drum and second drum. A transferring voltage applies to a side of the transfer belt for the first drum to transfer the first electrostatic image code onto the electrostatic image recording track. An electroconductive member is in parallel with the electrostatic image code and a surface of the electrostatic image code detected within a predetermined gap. An induced current generated in the electroconductive member relative to the lines of the electrostatic image codes which control the first drum or the second drum on the basis of a detection result of the detecting means such that the toner image on the second drum transferred onto a recording material on the transfer belt and overlaid on the toner image transferred onto the recording material from the first drum.

Image forming apparatus

An image forming apparatus which is capable of detecting the direction and amount of an image shift in the main scanning direction without wasting toner, to thereby provide a higher-quality image with reduced running costs. A conductor is disposed such that the conductor partially overlaps an electrostatic latent image line formed on a photosensitive drum in a manner extending in a main scanning direction of the photosensitive drum, while moving relative to the electrostatic latent image line. The conductor generates induced current by the relative motion. An image shift in the main scanning direction is detected based on a result of measurement of the induced current generated by the conductor.

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Kawasaki, Japan

Yuri Mizutani