Ajinomoto Co., Ltd.

Yuri Ivanovich Kozlov

Elena Vitalievna Klyachko

Mikhail Markovich Gusyatiner

Elvira Borisovna Voroshilova

Rustem Saidovich Shakulov

Aleksey Nikolaevich Marchenko

Sergey Vladimirovich Benevolensky

Rustam Saidovich Shakulov

Tatyana Abramovna Yampolskaya

Ekaterina Alekseevna Savrasova

Valery Zavenovich Akhverdian

Tatyana Aleksandrovna Bachina

Yurgis Antanas Vladovich Iomantas

Elena Georgievna Abalakina

Alla Markovna Kaplan

Andrey Olegovich Lobanov

Boris Mironovich Polanuer

The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.

Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine

A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genuswhich has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.

Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the AICAR transformylase-IMP cyclohydrolase encoded by the purH gene.

[object Object]

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene.

Method for producing L-histidine using bacteria of Enterobacteriaceae family

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talb gene.

There is disclosed a method for producing L-threonine using bacterium belonging to the genuswherein the bacterium has been modified to enhance an activity of aspartate-&#x3b2;-semialdehyde dehydrogenase.

A method for producing shikimic acid, comprising the steps of cultivating a bacterium belonging to the genus Bacillus which is deficient in shikimate kinase activity and has shikimic acid productivity, or a bacterium belonging to the genus Bacillus which is deficient in 5-enolpyruvylshikimate-3-phosphate synthase activity and has shikimic acid productivity, in an medium, producing and accumulating shikimic acid in the medium, and collecting shikimic acid from the medium.

Growing community of inventors

Moscow, Russia

Yuri Ivanovich Kozlov