Taisho Pharmaceutical Co., Ltd.

Nissan Chemical Industries Limited

Yuri Amada

Yoshinori Sekiguchi

Toshio Nakamura

Toshihito Kumagai

Taketoshi Okubo

Hiroshi Ohta

Tsuyoshi Shibata

Takaaki Ishii

Masato Hayashi

Shuji Yamamoto

Dai Nozawa

Takanori Shimizu

Takeshi Kuwada

Kumi Abe

Xiang-Min Sun

Takeshi Koami

Tomoko Ishizaka

Shigetada Sasako

Takayuki Nagatsuka

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MCreceptor antagonistic effect.

Aminopyrrolidine compound

It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle

An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of &#x3b1;2C-adrenoceptor and is useful in preventing and treating disorders attributable to &#x3b1;2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., 

Cyclic amine compound

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Tokyo, Japan

Yuri Amada