Tianjin Institute of Pharmaceutical Research Co., Ltd.

Tianjin Institute of Pharmaceutical Research

Yuqiang Liu

Lida Tang

Weiren Xu

Guilong Zhao

Yafei Xie

Meixiang Zou

Wei Liu

Yuli Wang

Yuquan Li

Huihui Chen

Jingwei Wu

Haizhi Zhang

Changying Liu

Peng Liu

Wei Wei

Bingni Liu

Jiang Wu

Jiajia Hou

Wen Du

Xuyuan Liu

Qian Shang

Zhixing Zhou

Chuan Li

The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

Crystal form of urate transporter 1 inhibitor and preparation method and use thereof

Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization. 

Method for preparing urate transporter 1 inhibitor

The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, 

Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof

The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R-Rare as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof. 

Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof

Phenyl C-glucoside derivative containing deoxyglucose structure, preparation method and use thereof

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Tianjin, China

Yuqiang Liu