Amgen Inc.

Yunxiao Li

Sean P Brown

Kexue Li

Joshua Taygerly

Brian Alan Lanman

Markian Myroslaw Stec

Ana Elena Minatti

Jonathan Dante Low

Xianghong Wang

Paul E Harrington

Todd J Kohn

Marc Vimolratana

Manuel Zancanella

Matthew R Kaller

Liusheng Zhu

Ming Yu

Alexander J Pickrell

Ana Zurisadai Gonzalez Buenrostro

Zhihong Li

Mike Elias Lizarzaburu

Kate Ashton

Brian Stuart Lucas

Nick A Paras

Julio Cesar Medina

Jonathan B Houze

Anthony B Reed

Xuelei Yan

Michael G Johnson

Yosup Rew

Felix Gonzalez Lopez De Turiso

Vu Van Ma

Alan C Cheng

Mario G Cardozo

Jason A Duquette

Yingcai Wang

Michael R Degraffenreid

Jiasheng Fu

Xian Yun Jiao

Michael W Gribble, Jr

Jiang Zhu

David Karl Bedke

Mike Elias Lizazaburu

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Compounds that inhibit Mcl-1 protein

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Compounds that inhibit MCL-1 protein

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stenoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. 

Macrocyclic compounds that inhibit MCL-1 protein

Compounds that inhibits MCL-1 protein

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Thousand Oaks, CA, United States of America

Yunxiao Li