Ohio University

Quidel Corporation

Diagnostic Hybrids, Inc.

Diagnostics Hybrid, Inc.

Yunsheng Li

David R Scholl

Leonard D Kohn

Giorgio Napolitano

Thomas E Wagner

Paul D Olivo

Xiaozhuo Chen

Jim Brown

James L Brown

Jaekyung Kim

Hannah Jaekyung Kim

The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions.

Compositions and methods for detecting autoantibodies

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.

Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity

The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the complex into cells. This system is capable of functioning in the cell cytoplasm without integration into the genome of host cells, and does not require host cell factors for initiation and maintenance of gene expression. Therefore, the invention has a wide range of applications in in vitro and in vivo gene expression, including gene therapy in resting cells.

Method for eliciting an immune response using a gene expression system

DNA polymerase gene expression system utilizing an RNA polymerase

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Athens, OH, United States of America

Yunsheng Li