University of California

Yunpeng Ma

Robert T O'Donnell

Derick H Lau

Joseph M Tuscano

The present invention provides compositions comprising the component of fermented wheat germ extract ('FWGE') active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors, and methods of making and using such compositions. The active component from FWGE comprises polypeptides having a molecular weight in the range of about 5-100 kiloDaltons (kD), for example, a molecular weight in the range of about 12-50 kD. Exemplary polypeptides from FWGE determined to be active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors are listed in Table 1.

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Chengdu, China

Yunpeng Ma