Shanghai Techwell Biopharmaceutical Co., Ltd.

Other

Shanghai Bioman Pharma Limited

Bn Pharmaceuticals Inc.

Yunman Zheng

Zhijun Tang

Bingming He

Zhonghao Zhuo

Xiaoming Ji

Ragina Naidu

Xiaoliang Gao

Tianhui Xu

Huichun Yang

Jushang Zheng

The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.

Cabazitaxel, related compounds and methods of synthesis

The present invention relates to a lubiprostone crystal, the method for the preparation thereof, and a pharmaceutical composition or kit comprising the same, as well as the use of said crystal in the preparation of a medicament for the treatment of gastrointestinal tract diseases, especially constipation. The X-ray powder diffraction pattern of said crystal comprises characteristic peaks measured at the following 2&#x3b8; reflection angles: 14.6&#xb1;0.2&#xb0;, 17.0&#xb1;0.2&#xb0; and 19.6&#xb1;0.2&#xb0;. As compared to amorphous lubiprostone, the crystal of the present invention has the advantages of relative high purity, stable properties and easy-for-storage and use.

Lubiprostone crystal, the use and the method for the preparation thereof

The crystalline form A of Bimatoprost of formula I, its preparation method and use are provided. There are characteristic peaks where diffraction angles 2&#x3b8; are 3.2&#xb1;0.2&#xb0;, 5.5&#xb1;0.2&#xb0;, 11.4&#xb1;0.2&#xb0;, 16.7&#xb1;0.2&#xb0;, 17.6&#xb1;0.2&#xb0;, 19.9&#xb1;0.2&#xb0;, 20.8&#xb1;02&#xb0; and 22.8&#xb1;0.2&#xb0; in the X-ray powder diffraction pattern of the crystalline form A.

Crystalline form of Bimatoprost, preparation method and use thereof

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Shanghai, China

Yunman Zheng