Ascentage Pharma (suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Shenyang Sunshine Pharmaceutical Co. Ltd.

University of Michigan

Jiangsu Ascentage Biomed Development Inc.

Ascentage Pharma Co., Ltd.

Yunlong Zhou

Yu Jing

Lingling Jiao

Ming Guo

Shaomeng Wang

Chao-Yie Yang

Ping Min

Suixiong Cai

Guangfeng Wang

Jianyong Chen

Chao Li

Hao Chen

Guozhi Tang

Liu Liu

Donna McEachern

Dajun Yang

Longchuan Bai

Wenming Chen

Dongbo Li

Binghua Sheng

Renlin Wang

Fang Liu

Wenliang Hu

Leilei Zhao

Chengzhe Wu

Xu Qian

The present disclosure provides compounds represented by Formula I, or an enantiomer or diastereomer, or a pharmaceutically acceptable salt thereof, wherein X, Y, Z, L, Ar, R, R, RR, R, R, m, and p are defined herein. Compounds of Formula I are BCR-ABL inhibitors. BCR-ABL inhibitors are useful for the treatment of cancer and other diseases.

Tricyclic compounds as BCR-ABL inhibitors

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, L, L, #, #, # are as defined as set forth in the re) specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Macrocyclic indoles as Mcl-1 inhibitors

Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, X, Y, Z, Z, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer. 

Macrocyclic spiroethers as Mcl-1 inhibitors

A compound of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein Rand Rare independently H; Ris selected from H, a C-Cstraight-chain, and a branched or cyclic alkyl; and R, R, R, R, and Rare each independently selected from C-Calkyl, halo C-Calkyl and the like. Also provided is a method for preparing the compound, pharmaceutical compositions including the compound or pharmaceutically acceptable salts thereof, and uses of the compound or pharmaceutically acceptable salt thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO. 

Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof

A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided. In particular, the compound has the following Formula (I), wherein Rand Rare each independently H; Ris H or C-Calkyl; Ar is an aromatic ring or a heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. Pharmaceutically acceptable salts of the present compound, are provided, as well as uses of the compound or pharmaceutically acceptable salts thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO. 

Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof

Disclosed are a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, a preparation method thereof, pharmaceutical compositions and uses thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO, wherein in the formula (I), Rand Rare each independently hydrogen; Ris hydrogen or Calkyl; and Ar is an aromatic ring or an heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. 

Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryl or heteroaryl, preparation method thereof and pharmaceutical use thereof

Disclosed herein are certain indoloquinolone compounds, methods of preparation thereof, pharmaceutical compositions thereof, and uses thereof, such as their uses as ALK inhibitors.

Indoloquinolone compounds as anaplastic lymphoma kinase (ALK) inhibitors

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Nanjing, China

Yunlong Zhou